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Abrazando la complejidad: conectando el trastorno afectivo bipolar, la hiperlaxitud articular y la neurodivergencia
Emily Bucknill1, Lisa Quadt1, Rebecca Dew2
1Department of Clinical Neuroscience, Brighton and Sussex Medical School, https://ror.org/01qz7fr76University of Sussex, Brighton, UK.
The British journal of psychiatry : the journal of mental science
|January 19, 2026
Resumen
La hiperlaxitud articular está relacionada con el trastorno bipolar, y los rasgos neurodivergentes como el autismo y el TDAH median esta conexión. Comprender estas interacciones es clave para la atención psiquiátrica personalizada.
Área de la Ciencia:
- Psiquiatría
- Genética
- Neurociencia
Sus antecedentes:
- La neurodivergencia incluye el autismo, el TDAH y el síndrome de Tourette.
- La hiperlaxitud articular se asocia con la neurodivergencia y el trastorno bipolar.
Objetivo del estudio:
- Determinar si la hiperlaxitud articular predice el trastorno bipolar.
- Investigar si las características neurodivergentes explican el vínculo entre la hiperlaxitud articular y el trastorno bipolar.
Principales métodos:
- Estudio de casos y controles con 52 pacientes con trastorno bipolar y 54 controles.
- Cribado de autismo, TDAH e hiperlaxitud articular.
- Análisis de mediación para evaluar el papel de la neurodivergencia.
Principales resultados:
- La hiperlaxitud articular predijo significativamente el trastorno bipolar (RM 5.1).
- La prevalencia de autismo y TDAH fue mayor en el grupo bipolar (84,6% y 65,4%).
- Los rasgos autistas y de TDAH mediaron la relación entre la hiperlaxitud articular y el trastorno bipolar.
Conclusiones:
- Los rasgos del desarrollo relacionados con la hiperlaxitud articular pueden explicar la fisiopatología afectiva.
- Las interacciones entre los rasgos físicos y neurodivergentes afectan la expresión de las enfermedades psiquiátricas.
- Los hallazgos tienen implicaciones para el diagnóstico, la medicina personalizada y el diseño de servicios.
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