Video Experimental Relacionado

Updated: Jan 21, 2026

Assaying Protein Kinase Activity with Radiolabeled ATP
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Assaying Protein Kinase Activity with Radiolabeled ATP

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Dominios SH3 activan selectivamente la quinasa PI3 a través de contactos terciarios no convencionales

Safia S Aljedani1,2,3, Anandsukeerthi Sandholu1, Abdullah Aldehaiman1

  • 1Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.

Communications biology
|January 19, 2026
PubMed
Resumen

Dominios específicos de Src homología 3 (SH3) activan la fosfoinositida-3 quinasa (PI3K) uniéndose a la subunidad p85. Este estudio revela que los dominios SH3 activan la PI3K a través de interacciones terciarias, no solo por la fuerza de unión, asegurando un control selectivo de las vías del cáncer.

Palabras clave:
dominios SH3PI3 quinasaactivación selectivainteracciones terciariassubunidad p85cáncer

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