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Updated: Jan 21, 2026

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry

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Sondas teranósticas de dualidad de modalidades: estrategias integradoras para el manejo de precisión de las

Xilin Jing^1,2,3, Yutao Li^1,2,3, Yijing Zhang⁴

¹Department of Thoracic Surgery, Peking University People's Hospital, Beijing 100044, China.

|January 20, 2026

Abstract:

Cancer remains a formidable global public health challenge. Recent advancements in immunotherapy and targeted therapies have revolutionized diagnostic and therapeutic paradigms. Within this context, theranostics-an emerging field integrating molecular imaging with therapeutic interventions-has shown promise in achieving precision oncology. Central to theranostic platforms are dual-modality probes utilizing positron emission tomography, fluorescence, and magnetic resonance imaging technologies, which offer synergistic advantages such as complementary imaging modalities, intraoperative guidance, and real-time drug delivery monitoring. Despite growing research interest and early clinical trials, critical challenges persist in biosafety, metabolic stability, and imaging resolution. Structural optimization of probes and modality-specific selection based on cancer subtypes may address these limitations. This review systematically evaluates the design principles and clinical applications of dual-modality probes and proposes actionable strategies to enhance their translational potential.

Palabras clave:

sondas de dualidad de modalidades imagen molecular oncología de precisión teranóstica

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