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Diagnóstico molecular rápido para la detección de Salmonella Typhi extensamente resistente a los medicamentos

Emma L Sweeney¹, Jacob A Tickner¹, Nicole G Ertl¹

¹The University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Australia.

The Journal of antimicrobial chemotherapy

|January 20, 2026

Resumen

Se desarrollaron herramientas de diagnóstico molecular rápido para Salmonella Typhi y resistencia a los antimicrobianos. Estos ensayos sensibles y específicos ofrecen una detección mejorada en entornos de bajos recursos, lo que ayuda a la terapia guiada por resistencia.

Sus antecedentes:

Salmonella Typhi causes over 160,000 deaths annually, disproportionately affecting children in endemic regions.
Current diagnostics lack sensitivity and require advanced infrastructure, limiting their use in low-resource settings.
Increasing antimicrobial resistance (AMR) in S. Typhi necessitates rapid diagnostic solutions.

Conclusiones:

Developed molecular assays provide options for targeted S. Typhi detection at the laboratory or point-of-care.
These tools can improve resistance-guided therapy for S. Typhi infections.
The assays are crucial given the rising prevalence of extensively drug-resistant (XDR) S. Typhi globally.

Palabras clave:

Salmonella Typhi resistencia a los antimicrobianos diagnóstico molecular PCR RPA-LF LAMP países de bajos y medianos ingresos terapia guiada por resistencia

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