Video Experimental Relacionado

Updated: Jan 22, 2026

Oral Biofilm Formation on Different Materials for Dental Implants

Oral Biofilm Formation on Different Materials for Dental Implants

Published on: June 24, 2018

Estudio sobre los efectos de las restauraciones de zirconia en prostodoncia oral sobre los niveles de factores

Wei Zhang¹, Fei Zou, Jun Xiong

¹Department of Dental, Huanggang Central Hospital, Huanggang, Hubei Province, China.

|January 21, 2026

Abstract:

This study aims to compare the effects of zirconia all-ceramic crowns and metal-ceramic crowns on inflammation and chewing function in patients receiving full-crown restorations and to explore whether improvements in gingival health mediate these effects - an aspect rarely addressed in previous studies. A total of 196 patients treated from January 2023 to January 2024 were included. After propensity score matching, 79 patients in each group had similar baseline characteristics. Serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) levels were measured before treatment and at 6 weeks and 3 months after restoration. Masticatory efficiency, visual analogue scale (VAS) scores, gingival condition, and clinical success were also evaluated. Both groups showed significant decreases in IL-6, TNF-α, and CRP after restoration, with greater reductions in the zirconia group (3-month IL-6: 7.2 ± 2.0 vs 9.8 ± 2.5 pg/mL; TNF-α: 11.5 ± 2.7 vs 14.3 ± 3.0 pg/mL; CRP: 3.5 ± 1.0 vs 4.8 ± 1.3 mg/L; all P < .001). The zirconia group also showed higher chewing efficiency (78.6 ± 9.2% vs 70.2 ± 8.9%), higher VAS scores (7.8 ± 1.0 vs 6.9 ± 1.1), and fewer gingival symptoms (7.6% vs 17.7%, all P < .05). Mediation analysis revealed that part of the CRP reduction was mediated by improved gingival health, providing novel mechanistic insight. This study not only confirms the superior clinical and anti-inflammatory effects of zirconia restorations over metal-ceramic crowns but also identifies gingival health as a potential mediator linking restorative material and systemic inflammation. These findings provide new evidence for the biological advantages of zirconia in prosthodontic practice.

Palabras clave:

tasa de éxito clínico salud gingival factores inflamatorios función masticatoria corona de metalcerámica corona de zirconia todo-cerámica

Más Videos Relacionados

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

Author Spotlight: Enhanced Method for Evaluating Analgesic Effects — Dual Hind Paw Carrageenan Injection in Mice

Author Spotlight: Enhanced Method for Evaluating Analgesic Effects — Dual Hind Paw Carrageenan Injection in Mice

Published on: November 15, 2024

Videos de Conceptos Relacionados

Restorative Care

Restorative Care

Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels

Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels

Renal clearance of a drug is influenced by various factors, including its physicochemical properties and plasma levels. These factors play a significant role in determining how efficiently the kidneys eliminate a drug.
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

Transcription Factors

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...