Video Experimental Relacionado
Updated: Jan 23, 2026

08:11
Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
Published on: November 11, 2022
3.5K
Un sistema en chip (SoC) de interfaz neuronal híbrido de 1024 canales con pinza de voltaje/corriente y adquisición
IEEE transactions on biomedical circuits and systems
|January 21, 2026
Resumen
Este estudio presenta un novedoso sistema en chip de interfaz neuronal (NISoC) para la investigación en neurociencia de alto rendimiento. Logra una eficiencia energética récord para la grabación y estimulación neuronal con capacidades integradas de compresión de datos.
Área de la Ciencia:
- Neurociencia
- Ingeniería Eléctrica
- Ciencia de Materiales
Sus antecedentes:
- La grabación y estimulación multimodales de alto rendimiento son cruciales para la neurociencia.
- La compresión de datos en el chip es esencial para reducir el volumen de datos en las interfaces neuronales.
- Las interfaces neuronales existentes enfrentan desafíos para equilibrar el área, la eficiencia energética y el rendimiento del ruido.
Objetivo del estudio:
- Desarrollar un sistema en chip de interfaz neuronal (NISoC) con un alto número de canales y eficiencia.
- Permitir la grabación y estimulación eléctrica simultánea de alta resolución.
- Integrar la adquisición y compresión de datos en el chip para reducir el volumen de datos.
Principales métodos:
- Fabricación de un NISoC de 1024 canales utilizando tecnología CMOS de 65 nm.
- Integración de un conjunto de electrodos de 32x32 con front-ends analógicos que admiten pinzas de voltaje y corriente.
- Implementación de 32 ADC SAR incrementales dinámicos para la adquisición de datos en el chip.
Principales resultados:
- Logró una eficiencia récord de ruido-energía con un consumo de energía de 0.81 µW/canal y un ruido de voltaje referido a la entrada de 8.8 µVrms.
- Demostró adquisición de datos de alto rendimiento a 25 Msps con 11 bits efectivos de número (ENOB).
- Logró una eficiencia energética de 2 fJ/nivel para la adquisición de datos.
Conclusiones:
- El NISoC desarrollado ofrece un avance significativo en la tecnología de interfaces neuronales para la investigación en neurociencia.
- El sistema proporciona electrofisiología de alta resolución y alto rendimiento con una eficiencia de ruido-energía excepcional.
- La detección de picos integrada en los ADC allana el camino para la futura compresión de datos neuronales en el chip.
Videos de Conceptos Relacionados
Voltage-gated Ion Channels
10.5K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
10.5K
Ion Channels
91.2K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.2K
Voltage
3.8K
The movement of electrons in a conductor requires some form of energy or work, usually provided by an external force, like a battery. This force is called the electromotive force or voltage. The voltage between two points, referred to as points "a" and "b," in an electric circuit is the energy (or work) needed to move a unit charge from point "a" to point "b," and this relationship is expressed mathematically as
3.8K
Protein-protein Interfaces
14.6K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.6K
Hybrid Zones
21.8K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
21.8K
Voltage Dividers
1.3K
In electrical circuits, resistors can be connected in series, sequentially linked one after the other. In a series configuration, the same current flows through each resistor. Ohm's law is a fundamental principle to understand the behavior of resistors in series. It expresses the voltage across these resistors in terms of the current and resistance.
Kirchhoff's voltage law implies that the sum of the voltages across the resistors in series equals the source voltage. This means that the current...
Kirchhoff's voltage law implies that the sum of the voltages across the resistors in series equals the source voltage. This means that the current...
1.3K

