Video Experimental Relacionado

Updated: Jan 23, 2026

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

Adyuvantes antimicrobianos derivados de productos naturales para revertir la resistencia bacteriana mediada por

Linyu Wu¹, Xinyuan Zhang¹, Peter Oelschlaeger²

¹Department of Forestry Chemical Engineering, Shaanxi Key Laboratory of Economic Plant Resources Development and Utilization, Forestry College, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China.

Journal of agricultural and food chemistry

|January 21, 2026

Abstract:

The clinical efficacy of β-lactams, polymyxins, and tetracyclines is especially increasingly compromised by plasmid-mediated resistance mechanisms. These include but are not limited to expression of β-lactamases (BLs), MCRs (encoded by the mcrs colistin resistance gene), and TetX (encoded by the tet(X3)/tet(X4) tetracycline resistance gene), which have constituted a significant menace to public health and food safety, triggering urgent concern worldwide. Combating this crisis requires innovative approaches, among which the development of antimicrobial adjuvants that synergize with existing antibiotics holds particular promise for reclaiming lost therapeutic efficacy. This review systematically summarizes the plasmid-mediated resistance mechanisms that inactivate β-lactams, polymyxins, and tetracyclines. Furthermore, we provide a detailed overview of all identified natural product chemotypes capable of inhibiting SBLs, MBLs, MCRs, and Tet(X3)/Tet(X4) enzymes or functioning as antimicrobial adjuvants along with their mechanisms of action. These findings establish fundamental principles to guide the development of broad-spectrum antimicrobial adjuvants aimed at counteracting plasmid-mediated bacterial resistance.

Palabras clave:

adyuvantes antimicrobianos resistencia bacteriana productos naturales resistencia mediada por plásmidos inhibidores de β-lactamasa

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