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Updated: Jan 23, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

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Proteínas en el Navegador Genómico: integración de filogenias, alineaciones y estructuras con evidencia a nivel de

Colin Diesh¹, Garrett Stevens¹, Caroline Bridge²

¹University of California, Berkeley, Dept of Bioengineering, Berkeley, CA, USA.

Journal of molecular biology

|January 21, 2026

Abstract:

Recent advances in protein structure prediction have created high-confidence candidate structures for every protein-coding gene in a genome. Concomitantly, many software packages have been created to visualize protein multiple sequence alignments (MSAs), protein structures, and protein annotations. However, few software tools can highlight the direct relationship between nucleotide variation of protein-coding genes in genome space and the evolutionary and structural context of that variation in protein space. To help address these needs, we created a suite of robust and reusable JavaScript components to show protein structures, MSAs, and phylogenies, and their relationship to protein-coding gene regions using the JBrowse 2 genome browser. This software allows users to interface with web services such as AlphaFoldDB to access pre-computed structures, or to upload protein structures from sources such as ColabFold or PDB. Our resources are available at https://github.com/GMOD/proteinbrowser.

Palabras clave:

Genómica comparativa Plegamiento de proteínas visualización de datos alineación de secuencias múltiples

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