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Assessment of Social Interaction Behaviors

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El BNST anterior es necesario para la interacción social impulsada por la novedad

Jessica T Jacobs¹, Mikaela L Aholt², Taylor Lineberry²

¹Division of Molecular and Integrative Physiology, Department of Biomedical Sciences, Southern Illinois University School of Medicine, Carbondale, IL, 62903 jjacobs65@siumed.edu jnordman78@siumed.edu.

The Journal of neuroscience : the official journal of the Society for Neuroscience

|January 21, 2026

Resumen

Los ratones prefieren interactuar con ratones desconocidos que con ratones conocidos. El núcleo anterior de la cama de la estría terminal (BNSTa) en el cerebro es clave para esta preferencia por la novedad social, promoviendo la participación con nuevos compañeros sociales.

Área de la Ciencia:

Neurociencia
Neurociencia conductual
Neurociencia computacional

Sus antecedentes:

La preferencia por la novedad social, la tendencia a interactuar con individuos desconocidos sobre los conocidos, es crucial para la supervivencia y la interacción social.
Esta preferencia se conserva en todas las especies, pero se altera en trastornos neuropsiquiátricos como el trastorno del espectro autista, la esquizofrenia y la ansiedad social.
Si bien se sabe que el hipocampo participa en la memoria del reconocimiento social, los circuitos neuronales que traducen la familiaridad en comportamiento siguen sin estar claros.

Objetivo del estudio:

Identificar los mecanismos neuronales subyacentes a la preferencia por la novedad social en ratones machos.
Investigar el papel del núcleo anterior de la cama de la estría terminal (BNSTa) en la mediación de las interacciones con congéneres desconocidos.

Principales métodos:

Se utilizó el marcaje con c-Fos, RNAscope, inmunohistoquímica y fotometría de fibra para examinar la actividad neuronal.
Se empleó la quimiogenética para inhibir selectivamente las neuronas dentro del BNSTa.
Se observaron las respuestas conductuales durante las interacciones sociales y la exploración de objetos novedosos.

Principales resultados:

Las neuronas inhibidoras y las que expresan DRD1 en el BNSTa se activaron ampliamente durante las interacciones con objetos sociales y novedosos.
La inhibición quimiogenética selectiva del BNSTa suprimió las interacciones con congéneres desconocidos.
Las interacciones con congéneres conocidos y objetos novedosos no se vieron afectadas por la inhibición del BNSTa.

Conclusiones:

El BNSTa se identifica como un nodo neural crítico que promueve el compromiso social impulsado por la novedad.
Este estudio revela un mecanismo de circuito para la preferencia por la novedad social, destacando el papel del BNSTa en el comportamiento social.
La disfunción en el BNST puede contribuir a los déficits sociales observados en trastornos neuropsiquiátricos.

Palabras clave:

novedad social BNSTa interacción social preferencia por la novedad neurociencia comportamiento social

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