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Tai Chi modulando patrones de conectividad multimodal y función cognitiva en la enfermedad de pequeños vasos
Xiaoyong Zhong1, Zhongpeng Dai2, Liuxi Chu3
1Department of Neurology and National Clinical Research Base of Traditional Chinese Medicine, The Affiliated People' s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, 350004, Fujian, China.
GeroScience
|January 21, 2026
Resumen
El ejercicio de Tai Chi mejoró significativamente la función cognitiva en pacientes con enfermedad de pequeños vasos cerebrales (EPVC). Esta intervención mente-cuerpo mejoró la conectividad cerebral y el acoplamiento estructural-funcional, ofreciendo un enfoque terapéutico potencial.
Área de la Ciencia:
- Neurociencia
- Neurología
- Medicina de Rehabilitación
Sus antecedentes:
- La enfermedad de pequeños vasos cerebrales (EPVC) es una causa importante de deterioro cognitivo y eventos cerebrovasculares.
- Las intervenciones mente-cuerpo como el Tai Chi muestran potencial para la mejora cognitiva y la plasticidad neural.
- Los mecanismos neurobiológicos que vinculan el Tai Chi con los beneficios cognitivos en pacientes con EPVC no se comprenden bien.
Objetivo del estudio:
- Investigar los mecanismos neurobiológicos subyacentes a la mejora cognitiva en pacientes con EPVC sometidos a Tai Chi.
- Examinar los efectos del Tai Chi sobre la función cognitiva, la homocisteína plasmática y la conectividad estructural y funcional (CE y CF) del cerebro.
Principales métodos:
- Un ensayo controlado aleatorizado de 24 semanas que involucró a 51 pacientes con EPVC asignados a Tai Chi o educación para la salud.
- Se realizaron evaluaciones neuropsicológicas, mediciones de homocisteína plasmática y análisis de CE/CF del cerebro.
- Se utilizaron estadísticas basadas en redes, análisis correlacionales y de mediación.
Principales resultados:
- El grupo de Tai Chi mostró una mejora significativa de la función cognitiva.
- Se observó un aumento de la conectividad funcional (CF) en las regiones frontoparieto-occipitales.
- El acoplamiento estructural-funcional mejorado en la red frontal medió parcialmente la reducción de homocisteína y las ganancias cognitivas.
Conclusiones:
- El ejercicio de Tai Chi impacta positivamente la función cognitiva en pacientes con EPVC.
- La intervención mejora la conectividad de la red cerebral y el acoplamiento estructural-funcional.
- El acoplamiento estructural-funcional de la red frontal puede mediar los efectos terapéuticos del Tai Chi en la EPVC.
Palabras clave:
Enfermedad de pequeños vasos cerebrales (EPVC)Deterioro cognitivo leve (DCL)Homocisteína plasmáticaAcoplamiento estructural-funcionalTai ChiMás Videos Relacionados
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