Video Experimental Relacionado

Updated: Jan 23, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Nobiletina promueve la curación de fracturas modulando la polarización de macrófagos: una revisión

Zhiqi Zhang¹, Shangyi Liu², Wenhao Li²

¹Department of Burn, Three Gorges University Hospital of Traditional Chinese Medicine & Yichang Hospital of Traditional Chinese Medicine, Yichang, China.

Frontiers in pharmacology

|January 22, 2026

Abstract:

Fracture healing is a complex process in which various cells, including macrophages, are involved. M1 macrophages and the cytokines they secrete exacerbate local inflammation and inhibit fracture healing, whereas M2 macrophages inhibit inflammation and promote tissue repair. An imbalance in the ratio of M1 to M2 macrophages leads to delayed healing and nonunion of the fracture. Nobiletin has received increasing attention in promoting fracture healing. Thus, the aim of this review article was to investigate the effects of nobiletin on macrophages during fracture healing, with a major focus on the potential mechanisms and applications, and to provide a reference for further research on this compound.

Palabras clave:

pseudoartrosis fractura inflamatorio polarización de macrófagos nobiletina

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