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Simbiosis del boro: un nuevo concepto en la comunicación huésped-microbioma

Andreea Silvia Pîrvu¹, Andrei Biţă^2,3, Ion Romulus Scorei⁴

¹Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

Frontiers in microbiology

|January 22, 2026

Resumen

El boro dietético influye en la comunicación microbiana intestinal al estabilizar moléculas de señalización y crear reservorios locales. Este marco de "simbiosis del boro" explica cómo el boro impacta la detección de quórum bacteriano (QS) y los fenotipos del huésped, con posibles beneficios o perjuicios.

Área de la Ciencia:

Microbiología y Bioquímica
Ciencia de la Nutrición
Biología de Sistemas

Sus antecedentes:

El boro (B) interactúa con moléculas biológicas como los dioles y los ésteres de fosfato.
El boro dietético forma grupos accesibles al plasma (PAB) y accesibles a la microbiota (MABC).
Los MABC influyen en la dinámica de las moléculas de señalización en la mucosa intestinal.

Objetivo del estudio:

Proponer el marco de 'simbiosis del boro'.
Explicar el papel del boro en la estabilización de intermedios de furanosil y la señalización AI-2.
Esbozar métodos para evaluar el impacto del boro en las comunidades microbianas intestinales y los fenotipos del huésped.

Principales métodos:

Espectroscopía de RMN de 11B resuelta en especiación.
Cromatografía líquida-espectrometría de masas (LC-MS) dirigida para AI-2 y AI-2B.
Cepas bacterianas reporteras con receptores AI-2 definidos.

Principales resultados:

El boro estabiliza los intermedios derivados de la 4,5-dihidroxipentano-2,3-diona (DPD) y el AI-2B.
Los MABC localizan el potencial químico en la superficie mucosal.
La influencia del boro en la dinámica del AI-2 puede depender del contexto, promoviendo o dificultando potencialmente el crecimiento microbiano.

Conclusiones:

El boro es un modulador plausible de las arquitecturas de detección de quórum (QS) microbiana intestinal.
El marco de simbiosis del boro predice la dieta → especificación de B → dinámica de AI-2 → fenotipos del huésped.
Los efectos de estabilización y localización mediados por el boro pueden ser ventajosos o perjudiciales para el huésped.

Palabras clave:

autoinductor-2–borato simbiosis del boro comunicación huésped-microbioma complejos de boro accesibles a la microbiota detección de quórum

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