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Evaluación de factores pronósticos mediante indicadores nutricionales en el cáncer de pulmón de células pequeñas en
Mamiko Kuriyama1, Makoto Nakao1, Ryohei Gomyo1
1Department of Respiratory Medicine, Kainan Hospital Aichi Prefectural Welfare Federation of Agricultural Cooperatives, Japan.
Journal of rural medicine : JRM
|January 22, 2026
Resumen
La puntuación de Glasgow (GPS) y el índice nutricional pronóstico (PNI) predicen los resultados en pacientes con cáncer de pulmón de células pequeñas en estadio extenso (ES-SCLC). La relación neutrófilos-linfocitos (NLR) no mostró un valor pronóstico significativo en esta cohorte de ES-SCLC.
Área de la Ciencia:
- Oncología
- Inmunonutrición
- Biomarcadores
Sus antecedentes:
- La puntuación de Glasgow (GPS), el índice nutricional pronóstico (PNI) y la relación neutrófilos-linfocitos (NLR) son indicadores pronósticos establecidos en diversos tipos de cáncer.
- Su significado pronóstico en el cáncer de pulmón de células pequeñas en estadio extenso (ES-SCLC) sigue siendo objeto de debate.
- El estado inmunonutricional es crucial para los resultados de los pacientes con cáncer.
Objetivo del estudio:
- Evaluar el valor pronóstico de la GPS, el PNI y la NLR en pacientes con ES-SCLC.
- Determinar si estos marcadores pueden predecir la supervivencia libre de progresión (PFS) y la supervivencia global (OS).
- Identificar marcadores inmunonutricionales fiables para el pronóstico del ES-SCLC.
Principales métodos:
- Análisis retrospectivo de 102 pacientes con ES-SCLC que recibieron quimioterapia de combinación de platino de primera línea.
- Evaluación de la GPS, el PNI y la NLR antes del inicio del tratamiento.
- Análisis de Kaplan-Meier y modelos de riesgos proporcionales de Cox para la evaluación de la PFS y la OS.
Principales resultados:
- La puntuación de Glasgow (GPS) (0/1) y el PNI más altos se asociaron significativamente con una mayor supervivencia libre de progresión (PFS) y supervivencia global (OS).
- No se observó ninguna diferencia significativa en la PFS o la OS para los grupos de NLR.
- El análisis multivariante confirmó la GPS y el PNI como predictores independientes de la PFS y la OS.
Conclusiones:
- La GPS y el PNI son indicadores pronósticos significativos para la PFS y la OS en pacientes con ES-SCLC.
- La GPS es un marcador simple y fiable para predecir los resultados en pacientes con ES-SCLC tratados con quimioterapia de combinación de platino.
- La NLR no es un factor pronóstico significativo en esta población de ES-SCLC.
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