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Tres casos malgaches de complicaciones óseas graves que revelan hiperparatiroidismo primario

Zolalaina Andrianadison¹, Lalao Nomenjanahary Rakotonirina², Oliva Henintsoa Rakotonirainy²

¹Department of Pediatric, Joseph Raseta Befelatanana University Hospital, Antananarivo, Madagascar.

Case reports in endocrinology

|January 22, 2026

Resumen

El hiperparatiroidismo primario (HPPT) puede causar graves problemas óseos, especialmente en adultos jóvenes. Este estudio destaca tres casos raros en los que el HPPT se presentó con importantes deformidades esqueléticas y fracturas, lo que retrasó el diagnóstico.

Área de la Ciencia:

Endocrinología
Trastornos metabólicos
Biología esquelética

Sus antecedentes:

El hiperparatiroidismo primario (HPPT) es un trastorno metabólico que causa hipercalcemia y niveles elevados de hormona paratiroidea (PTH).
Aunque es común en mujeres de mediana edad, el HPPT es raro en niños y adultos jóvenes.
Las formas no clásicas, como el HPPT de inicio temprano o normocalcémico, pueden conducir a un diagnóstico tardío y a graves complicaciones esqueléticas.

Objetivo del estudio:

Informar sobre tres casos clínicos de HPPT.
Ilustrar el HPPT que se presenta con deformidades esqueléticas catastróficas y fracturas patológicas.
Enfatizar la importancia de considerar el HPPT en pacientes jóvenes con complicaciones óseas graves.

Principales métodos:

Análisis de informes de casos.
Revisión de presentaciones clínicas.
Evaluaciones bioquímicas y radiológicas.

Principales resultados:

Tres pacientes presentaron deformidades esqueléticas graves y fracturas patológicas.
El diagnóstico de HPPT se retrasó significativamente debido a presentaciones clínicas inusuales.
Se observaron fenotipos de HPPT de inicio temprano y normocalcémico.

Conclusiones:

Las presentaciones inusuales de HPPT, particularmente en personas más jóvenes, pueden conducir a una morbilidad esquelética grave.
El diagnóstico y manejo tempranos del HPPT son cruciales para prevenir complicaciones óseas debilitantes.
Estos casos subrayan la necesidad de una mayor sospecha clínica de HPPT en pacientes con problemas esqueléticos inexplicables.

Palabras clave:

deformidad ósea niño fractura patológica hiperparatiroidismo primario calcio sérico

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