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Updated: Jun 16, 2026

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Aprovechamiento de la sal de Frémy para bioconjugaciones dirigidas a tirosina

Zachary V Samuels^1,2,3, Ava Stoddard^1,3,4, Wei-Siang Mark Kao^1,3

¹Department of Chemistry, Hunter College, City University of New York New York NY 10065 USA bz102@hunter.cuny.edu.

|January 22, 2026

Abstract:

The current bioconjugation toolbox overwhelmingly comprises strategies that modify lysine and cysteine residues within proteins and peptides. Herein, we have leveraged Frémy's salt (potassium nitrosodisulfonate) to create an approach to bioconjugation predicated on the oxidation of tyrosine residues and the subsequent strain-promoted oxidation-controlled quinone ligation between the resultant 1,2-quinones and trans-cyclooctene-bearing cargoes.

Palabras clave:

sal de Frémy bioconjugación oxidación de tirosina ligación de quinona química click modificación de proteínas

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