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Updated: Jan 23, 2026

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Efecto de zona post-zona en pruebas de flujo lateral de antígenos de Histoplasma puede causar resultados débiles o

Lieke Ten Have¹, Jochem B Buil^1,2, Karin van Dijk³

¹Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.

Medical mycology

|January 22, 2026

Abstract:

In this article, we evaluate a possible postzone effect for the Histoplasma antigen Lateral Flow Assay (LFA). We re-tested urine samples that were Histoplasma-positive with the LFA, both for an undiluted and diluted sample. Of the twelve samples, a postzone effect was observed in six, and in one sample this led to a false negative result in the undiluted sample. For two samples, dilution of the sample led to a weaker LFA result. We recommend cautiousness when interpreting negative samples based on LFA alone, especially when clinical suspicion of histoplasmosis is high.

Palabras clave:

Prueba de antígeno Diagnóstico Micosis endémicas Histoplasma Ensayo de flujo lateral

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