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Dupilumab como terapia de mantenimiento en enteritis eosinofílica dependiente de esteroides: un enfoque
Íñigo Roa Esparza1, Irene Arteagoitia Casero2, Mario Salvador Argueta Valdez1
1Gastroenterology, Hospital Universitario de Cruces, Spain.
Revista espanola de enfermedades digestivas
|January 22, 2026
Resumen
Este estudio de caso explora dupilumab como terapia de mantenimiento que ahorra esteroides para la enteritis eosinofílica. Muestra potencial para la interrupción de los corticosteroides y la remisión sostenida en un paciente dependiente de esteroides.
Área de la Ciencia:
- Gastroenterología
- Inmunología
- Farmacología
Sus antecedentes:
- La enteritis eosinofílica es una afección inmunomediada rara.
- Los tratamientos actuales se basan en corticosteroides sistémicos para los brotes, pero carecen de una terapia de mantenimiento estandarizada.
- La enfermedad recurrente a menudo requiere ciclos repetidos de esteroides.
Objetivo del estudio:
- Evaluar la eficacia de dupilumab fuera de indicación como terapia de mantenimiento que ahorra esteroides.
- Evaluar el potencial de interrupción de los corticosteroides en un paciente con enteritis eosinofílica dependiente de esteroides.
Principales métodos:
- Informe de caso de un hombre de 27 años con enteritis eosinofílica dependiente de esteroides.
- Evaluación multidisciplinaria para excluir otras causas de eosinofilia.
- Inicio de terapia con dupilumab fuera de indicación.
- Seguimiento de un año.
Principales resultados:
- El paciente logró la interrupción completa de los corticosteroides con dupilumab.
- Se mantuvo la remisión sostenida durante un año.
- Se observó buena tolerabilidad de dupilumab.
- El paciente pudo reintroducir alimentos restringidos.
Conclusiones:
- Dupilumab muestra potencial como terapia de mantenimiento eficaz que ahorra esteroides para pacientes seleccionados con enteritis eosinofílica.
- Este enfoque puede mejorar la calidad de vida al permitir la reintroducción de la dieta.
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