Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

Direct Motor Pathways01:11

Direct Motor Pathways

4.3K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
4.3K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

9.8K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.8K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

8.4K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
8.4K
Leaving Groups02:14

Leaving Groups

9.6K
The nature of leaving groups strongly influences the outcome of a nucleophilic substitution reaction.
In general, in a nucleophilic substitution reaction, a nucleophile displaces a functional group, called the leaving group, from the substrate to give a substituted product. A leaving group departs the substrate molecule through heterolytic cleavage, taking the pair of electrons with it to become a relatively stable weak base in the form of an anion or a neutral molecule.  
In a...
9.6K
Phosphate Buffer01:22

Phosphate Buffer

4.9K
The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
4.9K
C4 Pathway and CAM01:27

C4 Pathway and CAM

48.9K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
48.9K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates.

Nature communications·2026
Same author

Chirality Makes or Breaks Chemically Driven Self-Assembly.

Angewandte Chemie (International ed. in English)·2025
Same author

Self-Assembling Amphiphilic ABA Triblock Copolymers of Hyperbranched Polyglycerol with Poly(tetrahydrofuran) and Their Nanomicelles as Highly Efficient Solubilization and Delivery Systems of Curcumin.

International journal of molecular sciences·2025
Same author

Selective peptide bond formation via side chain reactivity and self-assembly of abiotic phosphates.

Nature communications·2025
Same author

Simultaneous Formation of a Foldamer and a Self-Replicator by Out-of-Equilibrium Dynamic Covalent Chemistry.

Journal of the American Chemical Society·2024
Same author

Tailoring Porous N-Doped Carbon Nanospheres for 3D Bottom-Up Electrode Design: A Versatile Synthesis Toolbox for Particle Size Independent Pore Size Control.

Small (Weinheim an der Bergstrasse, Germany)·2024
Same journal

Decoding Galectin-Glycan Recognition with <sup>19</sup>F-Tagged Lectins: from Simple Glycans to the Cellular Glycocalyx.

Journal of the American Chemical Society·2026
Same journal

Open- and Closed-Shell Roles of Sensitizer and Annihilator in Pseudo-Single Component Mixtures for Upconversion.

Journal of the American Chemical Society·2026
Same journal

Pressure-Induced Superconductivity at 15 K in van-der-Waals Ferroelectric CuInP<sub>2</sub>S<sub>6</sub>.

Journal of the American Chemical Society·2026
Same journal

Carbene Analogues of Group 15: Reduction of s-Hydrindacene-Based Chloropnictogenium Ions To Access an Antimony Hydride Monocation and a Trinuclear Bismuth Dication.

Journal of the American Chemical Society·2026
Same journal

Chiral-Ligand-Modulated Nickel-Catalyzed Stereoselective Radical Migratory C2-Arylation of Carbohydrates.

Journal of the American Chemical Society·2026
Same journal

Coordination-Constraint-Driven Enhanced Chirality Induction in Perovskite Quantum Dot Solids.

Journal of the American Chemical Society·2026
Ver todos los artículos relacionados
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: Jan 24, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

3.9K

Grupos de salida de fosfato personalizados de autoensamblaje dependiente de la vía directa

Arti Sharma1,2, Kun Dai3, Mahesh D Pol2,3

  • 1Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT), University of Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany.

Journal of the American Chemical Society
|January 22, 2026
PubMed
Resumen
Este resumen es generado por máquina.

El estudio revela que el grupo de salida en los fosfatos aminoacilo influye significativamente en la formación de enlaces péptidos y en el autoensamblaje. Los grupos de salida variables controlan la reactividad, la estructura supramolecular y la selectividad de la secuencia en entornos acuosos.

Más Videos Relacionados

Olfactory Context Dependent Memory: Direct Presentation of Odorants
04:47

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

7.1K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.9K

Videos de Experimentos Relacionados

Last Updated: Jan 24, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

3.9K
Olfactory Context Dependent Memory: Direct Presentation of Odorants
04:47

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

7.1K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.9K

Área de la Ciencia:

  • La bioquímica
  • Química supramolecular
  • Biología Química

Sus antecedentes:

  • Los ésteres de fosfato y los anhídridos son cruciales para la transferencia de energía biológica.
  • Los fosfatos acilo son altamente reactivos, generalmente se activan a través de adenilatos aminoacilo.
  • Los grupos de salida alternativos para los fosfatos acilo siguen siendo en gran medida inexplorados con respecto a su impacto en la reactividad y la estructura.

Objetivo del estudio:

  • Investigar cómo los grupos de salida de fosfato influyen en la formación de enlaces péptidos y en su autoensamblaje en el agua.
  • Para explorar el papel de salir de la estructura de grupo en la dirección de la organización supramolecular y la reactividad.
  • Comprender cómo los grupos de salida transforman los fosfatos aminoacílicos en elementos de diseño activos para la selectividad de la secuencia.

Principales métodos:

  • Síntesis de ésteres de fosfato aminoacílico con diversos grupos de salida (etil, fenil, naftil y dodecil).
  • Caracterización de la formación de enlaces péptidos y el autoensamblaje en soluciones acuosas.
  • Análisis de las arquitecturas supramoleculares y las propiedades mecánicas de los conjuntos resultantes.
  • Investigación de la dinámica del intercambio de fosfilo en los fosfatos solubles frente a los autoensambladores.

Principales resultados:

  • Dejar la estructura del grupo dicta vías distintas para la formación de enlaces péptidos y el autoensamblaje.
  • La preorganización en agregados y el coensamblaje con péptidos se guían dejando características de grupo.
  • Dejar grupos determina los rendimientos de los péptidos, las arquitecturas supramoleculares y las propiedades mecánicas.
  • Los fosfatos aminoacílicos actúan como elementos de reconocimiento, impulsando la selectividad de la secuencia a través de microambientes.
  • Los fosfatos de autoensamblaje resisten el intercambio y promueven la oligomerización de aminoácidos, a diferencia de las contrapartes solubles.

Conclusiones:

  • El grupo de salida es un elemento sintonizable que rige la reactividad del fosfato aminoacílico y la dinámica de la vía.
  • Los grupos de abandono dirigen activamente los procesos de organización, montaje y reconocimiento supramoleculares.
  • Este trabajo transforma la química de activación de un simple paso sintético en un motor de resultados biológicos complejos.