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Novedad del Péptido Dirigido a FGFR4 para la Tomografía Computarizada de Emisión de Fotón Único en Carcinoma

Qiurong Ju¹, Xiaohui Wang¹, Yutong Chen¹

¹State Key Laboratory of Natural Medicine, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, No. 24 Tongjia Lane, Gulou District, Nanjing 211198, China.

Journal of medicinal chemistry

|January 23, 2026

Abstract:

Fibroblast growth factor receptor 4 (FGFR4) is overexpressed in various malignancies, making it a promising target for tumor diagnosis. In this study, we designed a series of FGFR4-targeted peptide-radionuclide conjugates (PRCs) based on a high-affinity peptide ligand derived from the binding epitope of the monoclonal antibody U3-1784. FYQ-8 showed the highest binding affinity for FGFR4-high-expressing HepG2 cells and was selected for radiolabeling with ⁹⁹^mTc via HYNIC, yielding ⁹⁹^mTc-HYNIC-FYQ-8. In xenograft models, this probe demonstrated high uptake (1.89 ± 0.35% ID/g) and produced high-contrast images specifically in high-FGFR4-expressing tumors. These results indicate that ⁹⁹^mTc-HYNIC-FYQ-8 is a promising peptide-based radiotracer for clinical imaging of FGFR4-overexpressing tumors.

Palabras clave:

FGFR4 hepatocellular carcinoma peptide-radionuclide conjugate radiotracer single-photon emission computed tomography

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