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Antígeno Soluble en Array que Muestra Proinsulina(F25D) Dirige Selectivamente Células B Antiinsulina sin Efectos
Grant M Downes1, Kyle D Apley2, Gang Hu3
1Bioengineering Graduate Program, University of Kansas, Lawrence, Kansas 66045, United States.
Molecular pharmaceutics
|January 23, 2026
Resumen
Un novedoso antígeno soluble en array (SAgA) dirigido a la proinsulina mutada (M-PI(F25D)) muestra promesa para la inmunoterapia específica de antígenos (ASIT) en la diabetes tipo 1 (DT1). Este enfoque evita los efectos glucémicos mientras se dirige específicamente a las células B autorreactivas y a los anticuerpos antiinsulina.
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