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Los niveles del factor reumatoide se asocian con la exacerbación de la artritis después de la interrupción de la
Yusuke Ogata1, Masumi Bamba1, Koichi Bamba1
1Takikawa Municipal Hospital, Takikawa, Hokkaido, Japan.
International journal of rheumatic diseases
|January 23, 2026
Resumen
Los niveles altos de factor reumatoide (≥28 U/mL) predicen la exacerbación de la artritis después de suspender la bucillamina, una alternativa al metotrexato. El factor reumatoide puede identificar a los pacientes que se benefician de la continuación de la terapia con bucillamina para la artritis reumatoide.
Área de la Ciencia:
- Reumatología
- Inmunología
- Farmacología
Sus antecedentes:
- La bucillamina es un fármaco antirreumático modificador de la enfermedad (FAME) que se utiliza como alternativa al metotrexato para la artritis reumatoide (AR).
- Identificar a los pacientes que se benefician del tratamiento con bucillamina es crucial para optimizar el manejo de la AR.
- Una escasez nacional de suministro de bucillamina en 2021 obligó a suspender el tratamiento de algunos pacientes con AR.
Objetivo del estudio:
- Determinar qué pacientes con artritis reumatoide se benefician de la continuación de la terapia con bucillamina.
- Investigar el valor predictivo de las características clínicas basales para la exacerbación de la artritis después de la interrupción de la bucillamina.
Principales métodos:
- Estudio retrospectivo de seguimiento de pacientes con AR que suspendieron la bucillamina en 2021.
- Comparación de las características basales entre los pacientes que experimentaron exacerbación de la artritis y aquellos que no.
- Análisis de los niveles de factor reumatoide (FR) como posible predictor de exacerbación utilizando análisis ROC y Kaplan-Meier.
Principales resultados:
- Trece de 18 pacientes (72%) experimentaron exacerbación de la artritis después de la interrupción de la bucillamina.
- Los pacientes que experimentaron exacerbación tuvieron niveles basales de FR significativamente más altos (49 U/mL) en comparación con aquellos que no (6 U/mL).
- Los niveles basales de FR ≥28 U/mL predijeron la exacerbación de la artritis con un 76,2% de sensibilidad y un 80,0% de especificidad.
Conclusiones:
- Las exacerbaciones de la artritis son comunes después de la interrupción de la bucillamina, particularmente en pacientes con niveles basales de FR más altos.
- Los niveles elevados de FR basales (≥28 U/mL) sirven como biomarcador para predecir la exacerbación en pacientes con AR después de suspender la bucillamina.
- Los niveles de FR pueden ayudar a identificar a los pacientes con AR que pueden beneficiarse de la continuación de la terapia con bucillamina para prevenir brotes de la enfermedad.
Palabras clave:
Japónexacerbación de la artritisbucillaminafármacos antirreumáticos modificadores de la enfermedad sintéticos convencionalesartritis reumatoidefactor reumatoidesuspensión del tratamientoMás Videos Relacionados
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