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Updated: Jan 24, 2026

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain
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Base estructural de cómo los estreptococos viridans con capacidad de unión a sialoglicanos acomodan ligandos que

KeAndreya M Morrison1, Kole Martin2, Hai Yu3

  • 1Department of Pharmacology, Meharry Medical College, Nashville, TN, US.

microPublication biology
|January 23, 2026
PubMed

Durante las infecciones endocárdicas, los estreptococos del grupo viridans utilizan proteínas que contienen regiones de unión semejantes a siglec para unirse a los ácidos siálicos terminados en sialatoO-GalNAc glicanos en el glicoproteína plaquetaria GPIbα. Gran parte del trabajo previo utilizó ligandos parciales aislados de di-, tri- o tetrasacáridos para investigar esta unión de sialoglicanos. Aquí, informamos la estructura cristalina con una resolución de 1,9 Å delStreptococcus gordoniila región de unión similar a Siglec de la cepa M99 unida a un trisacárido del antígeno sialil-T (sTa) ligado a L-serina. La estructura demuestra cómo se acomodan las extensiones del trisacárido, con implicaciones para la unión de ligandos sialoglicanos más grandes.

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