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Updated: Jan 24, 2026

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Evaluación comparativa de adyuvantes para mejorar las respuestas de anticuerpos a una vacuna contra la malaria basada

Yogesh Nepal, Alexandra Francian, Bryce T Roberts

bioRxiv : the preprint server for biology

|January 23, 2026

Abstract:

Effective pre-erythrocytic Plasmodium falciparum vaccines targeting circumsporozoite protein (CSP) must elicit strong and durable antibody responses. We assessed the ability of different classes of adjuvants to enhance immunity of a promising CSP-epitope-targeted virus-like particle (VLP)-based vaccine. Five formulations significantly increased anti-CSP IgG titers and several also enhanced antibody durability. This study identifies promising adjuvants that enhance both the magnitude and longevity of VLP-induced immunity.

Palabras clave:

malaria vacuna adyuvante anticuerpo inmunogenicidad Plasmodium falciparum proteína circumsporozoito CSP VLP inmunidad

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