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Updated: Jan 24, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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Definición de un protocolo clínico mediante una batería central computarizada de procesamiento visual

Marcelo Fernandes Costa1, Leonardo Dutra Henriques1, Givago Silva Souza2

  • 1Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, Av. Prof. Mello Moraes 1721, Butanta, 05508-030, São Paulo, SP, Brasil.

MethodsX
|January 23, 2026
PubMed
Resumen

Un nuevo protocolo computarizado evalúa con precisión el Procesamiento Visual Central (PVC), integrando funciones sensoriales, perceptivas y cognitivas. Esta herramienta fiable mejora la evaluación visual en las vías dorsal y ventral.

Palabras clave:
Atención automáticaVía dorsalProcesamiento globalProcesamiento localEstimación cuantitativaSpan de lecturaMemoria espacialAtención sostenidaVía ventralPercepción visualEvaluación del procesamiento visualTrastorno del procesamiento visual

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Área de la Ciencia:

  • Neurociencia
  • Oftalmología
  • Psicología Cognitiva

Sus antecedentes:

  • Las herramientas actuales de evaluación visual tienen limitaciones para evaluar funciones visuales complejas.
  • El Procesamiento Visual Central (PVC) implica funciones sensoriales, perceptivas y cognitivas integradas dentro de las vías dorsal y ventral.
  • Existe la necesidad de una herramienta de evaluación integral, clínicamente factible y psicofísicamente válida.

Objetivo del estudio:

  • Desarrollar y validar un protocolo clínico computarizado para la evaluación del Procesamiento Visual Central (PVC).
  • Integrar funciones visuales sensoriales, perceptivas y cognitivas en las vías dorsal y ventral.
  • Asegurar la viabilidad clínica y la validez psicofísica en la evaluación visual.

Principales métodos:

  • Se desarrolló una batería computarizada con tareas psicofísicamente controladas que miden diversas funciones visuales (p. ej., sensibilidad al contraste, atención visual, movimientos oculares).
  • Se utilizó software de presentación de alta precisión y se adaptaron los procedimientos a entornos clínicos.
  • Se validó el protocolo con 41 adultos sanos utilizando análisis de reevaluación, alfa de Cronbach y fiabilidad de mitades partidas.

Principales resultados:

  • No se encontraron diferencias significativas entre las evaluaciones de reevaluación (p > 0.05).
  • Los índices de fiabilidad demostraron una fuerte consistencia interna en todas las subpruebas.
  • El protocolo mostró alta reproducibilidad y solidez metodológica.

Conclusiones:

  • El protocolo computarizado desarrollado es una herramienta fiable y válida para la evaluación del Procesamiento Visual Central (PVC).
  • Ofrece un enfoque integral que integra múltiples funciones visuales en las vías de procesamiento.
  • El rigor psicofísico y la viabilidad clínica del protocolo lo hacen adecuado para aplicaciones de investigación y clínicas.