Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.7K
pH Scale02:41

pH Scale

79.1K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
79.1K
Scaling01:26

Scaling

571
In designing and analyzing filters, resonant circuits, or circuit analysis at large, working with standard element values like 1 ohm, 1 henry, or 1 farad can be convenient before scaling these values to more realistic figures. This approach is widely utilized by not employing realistic element values in numerous examples and problems; it simplifies mastering circuit analysis through convenient component values. The complexity of calculations is thereby reduced, with the understanding that...
571
Ribosome Profiling02:24

Ribosome Profiling

4.1K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.1K
Depth Perception and Spatial Vision01:15

Depth Perception and Spatial Vision

1.9K
Depth perception is the ability to perceive objects three-dimensionally. It relies on two types of cues: binocular and monocular. Binocular cues depend on the combination of images from both eyes and how the eyes work together. Since the eyes are in slightly different positions, each eye captures a slightly different image. This disparity between images, known as binocular disparity, helps the brain interpret depth. When the brain compares these images, it determines the distance to an object.
1.9K
Thermometers and Temperature Scales01:22

Thermometers and Temperature Scales

7.2K
Any physical property that depends consistently and reproducibly on temperature can be used as the basis of a thermometer. For example, volume increases with temperature for most substances. This property is the basis for the common alcohol thermometer and the original mercury thermometers. Other properties used to measure temperature include electrical resistance, color, and the emission of infrared radiation.
As many physical properties depend on temperature, the variety of thermometers is...
7.2K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Agentic AI for Spatial Omics.

Immunology and cell biology·2026
Same author

Dissecting non-small cell lung cancer (NSCLC) with blood proteomics-from surgical to immunotherapeutic responses.

NPJ precision oncology·2026
Same author

Tertiary lymphoid structures in head and neck squamous cell carcinoma as predictors of response to immunotherapy.

Oral oncology·2026
Same author

Defining the tumor microenvironment of non-small cell lung cancer.

Immunology and cell biology·2026
Same author

Spatial multi-omics characterization of neuroblastoma reveals ferroptosis-associated metabolic features in high-risk tumors.

Genome medicine·2026
Same author

Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature.

Cell reports. Medicine·2026

Video Experimental Relacionado

Updated: Jan 25, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.7K

Perfilado espacial a gran escala del microambiente del tumor en el cerebro.

Aaron Kilgallon1, Rafael Tubelleza1, Arutha Kulasinghe1

  • 1Queensland Spatial Biology Centre, Wesley Research Institute, Brisbane, QLD, Australia; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia.

Cell
|January 23, 2026
PubMed
Resumen

Los investigadores analizaron el microambiente inmune tumoral en más de 14.000 pacientes utilizando proteomía de inmunofluorescencia múltiple. Este análisis expansivo ayuda en el descubrimiento del cáncer y la estratificación del paciente.

Más Videos Relacionados

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

12.0K
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.7K

Videos de Experimentos Relacionados

Last Updated: Jan 25, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.7K
Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

12.0K
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.7K

Área de la Ciencia:

  • La biología espacial es la biología espacial.
  • La proteómica es la proteómica.
  • Investigación de la investigación del cáncer.

Sus antecedentes:

  • La proteómica de la inmunofluorescencia múltiple es clave para comprender la arquitectura del tejido y los estados celulares.
  • El microambiente inmune del tumor tiene un impacto significativo en la progresión del cáncer y la respuesta al tratamiento.

Objetivo del estudio:

  • Para realizar un análisis poblacional a gran escala del microambiente inmune del tumor.
  • Aprovechar las técnicas de biología espacial para el descubrimiento clínico y la estratificación del paciente.

Principales métodos:

  • Desarrollo de GigaTIME, una nueva plataforma analítica.
  • Aplicación de la proteómica de inmunofluorescencia múltiple a más de 14.000 muestras de pacientes.
  • Análisis a través de 24 tipos distintos de cáncer.

Principales resultados:

  • Caracterización del microambiente inmune del tumor a una escala sin precedentes.
  • Identificación de patrones y biomarcadores para el descubrimiento clínico.
  • Demostración de la utilidad de GigaTIME en la estratificación del paciente.

Conclusiones:

  • GigaTIME permite un análisis robusto del microambiente inmune del tumor.
  • La proteómica espacial a gran escala facilita importantes conocimientos clínicos en oncología.
  • Este enfoque es prometedor para el avance de la oncología de precisión.