Video Experimental Relacionado

Updated: Jan 25, 2026

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro
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Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

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Estableciendo la relación entre la senescencia celular cerebral y la estructura cerebral

Anina N Lund1, Brian H Kopell2, Negar Golestani1

  • 1Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Cell
|January 23, 2026
PubMed
Resumen

La senescencia celular, un proceso relacionado con el envejecimiento, se correlaciona con la atrofia cerebral. Este estudio revela mecanismos moleculares compartidos en el desarrollo y envejecimiento del cerebro, particularmente en las neuronas y la microglía, que impactan en la estructura del cerebro.

Palabras clave:
envejecimientoel cerebroSección de ARN a graneldesarrolloEspectrometría de masasmultiómicaenvejecimientode un solo núcleo RNA-seqImágenes por resonancia magnética estructural

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