Video Experimental Relacionado

Updated: Jul 14, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Fluidez verbal en la enfermedad de Parkinson con deterioro cognitivo leve: análisis cuantitativo, cualitativo y de

Alfonso Delgado-Álvarez¹, Lucía Fernández-Romero², María Valles-Salgado²

¹Department of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdiSSC), Universidad Complutense de Madrid, Spain; Department of Psychobiology & Behavioral Sciences Methods, Universidad Complutense de Madrid, Spain.

Parkinsonism & related disorders

|January 25, 2026

Resumen

Los pacientes con enfermedad de Parkinson con deterioro cognitivo leve (EP-DCL) presentan déficits significativos en la fluidez verbal semántica en comparación con aquellos sin deterioro cognitivo (EP-sDCL). El análisis de redes semánticas revela una menor cohesión local en la EP-DCL, lo que afecta el rendimiento cognitivo.

Área de la Ciencia:

Neurociencia; Psicología Cognitiva; Neurología

Sus antecedentes:

Las tareas de fluidez verbal (FV) son estándar en la evaluación cognitiva de la enfermedad de Parkinson (EP).; Las métricas actuales, como el número total de respuestas correctas, no capturan completamente los matices del rendimiento ni los mecanismos cognitivos subyacentes.

Objetivo del estudio:

Comparar la fluidez verbal semántica y fonémica (FV) en pacientes con EP y deterioro cognitivo leve (EP-DCL) frente a aquellos sin él (EP-sDCL).; Identificar predictores neuropsicológicos del rendimiento de la FV y analizar las estructuras de las redes semánticas en ambos grupos.

Principales métodos:

Ochenta participantes con EP (50% EP-DCL) se sometieron a pruebas neuropsicológicas completas y a dos tareas de FV.; Las medidas incluyeron respuestas correctas, clústeres, intercambios e intrusiones; la regresión lineal identificó predictores.; Se compararon cuantitativa y cualitativamente los mapas de redes semánticas entre los grupos EP-DCL y EP-sDCL.

Principales resultados:

Los pacientes con EP-sDCL mostraron un rendimiento significativamente mejor en respuestas correctas, clústeres semánticos e intercambios en comparación con los de EP-DCL.; La fluidez semántica fue predicha por la memoria episódica, la denominación y la atención; la fluidez fonémica por la atención, la memoria de trabajo y las funciones ejecutivas.; El análisis de redes semánticas reveló una menor longitud del camino más corto y un menor coeficiente de agrupamiento en la EP-DCL, lo que indica una menor cohesión semántica local.

Conclusiones:

Los pacientes con EP-DCL demuestran déficits pronunciados en la fluidez semántica, caracterizados por menos clústeres e intercambios.; Las alteraciones de la red semántica en la EP-DCL sugieren una cohesión semántica local comprometida, lo que afecta la función cognitiva.

Palabras clave:

Evaluación cognitiva Deterioro cognitivo leve Enfermedad de Parkinson Análisis de redes semánticas Fluidez verbal

Más Videos Relacionados

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Videos de Conceptos Relacionados

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

Parkinson Disease l: Introduction

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...

Parkinson Disease ll: Pathophysiology

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...