Video Experimental Relacionado
Updated: Jan 28, 2026
07:59
Author Spotlight: Real-Time Monitoring of Parasite Burden and Host Response
Published on: May 31, 2024
2.1K
La negentropía es el verdadero objetivo farmacológico de las enfermedades crónicas
Rui Li1, Tian-Le Gao2, Gang Ren1
1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Acta pharmaceutica Sinica. B
|January 26, 2026
Resumen
Proponemos una nueva estrategia de descubrimiento de fármacos dirigida a las "moléculas cabeza de ganso" (MCG) para combatir las enfermedades crónicas aumentando los mecanismos negentrópicos naturales del cuerpo, lo que conduce a tratamientos que abordan las causas raíz.
Área de la Ciencia:
- Bioquímica y Biología Molecular
- Farmacología
- Biología de Sistemas
Sus antecedentes:
- Las enfermedades crónicas se derivan de mecanismos moleculares complejos, lo que dificulta el descubrimiento de fármacos.
- El aumento de la entropía en el cuerpo humano se identifica como una causa raíz de las enfermedades crónicas.
Objetivo del estudio:
- Introducir el concepto de ;moléculas cabeza de ganso; (MCG) para dirigirse a los mecanismos negentrópicos.
- Proponer el novedoso eje ;MCG-negentropía-dCloud; como estrategia de descubrimiento de fármacos para enfermedades crónicas.
Principales métodos:
- Identificación de moléculas clave (MCG) cruciales para las funciones negentrópicas.
- Investigación del papel de las MCG en el mantenimiento de la homeostasis.
- Conceptualización del efecto de nube de fármacos (dCloud) mediado por negentropía para la intervención terapéutica.
Principales resultados:
- Se proponen las MCG como objetivos críticos para activar los mecanismos negentrópicos inherentes.
- La intervención farmacológica dirigida a las MCG puede reprogramar los procesos de la enfermedad a través del efecto dCloud.
- Este enfoque tiene como objetivo tratar tanto los síntomas como las causas raíz de las enfermedades crónicas.
Conclusiones:
- El eje ;MCG-negentropía-dCloud; ofrece un nuevo paradigma para el descubrimiento de fármacos en enfermedades crónicas.
- Esta estrategia se centra en restaurar el orden a partir del desorden, a diferencia de las intervenciones de un solo objetivo.
- Los fármacos clínicamente validados dirigidos a las MCG ejemplifican el potencial de este enfoque.
Videos de Conceptos Relacionados
02:39Entropy
35.4K
Salt particles that have dissolved in water never spontaneously come back together in solution to reform solid particles. Moreover, a gas that has expanded in a vacuum remains dispersed and never spontaneously reassembles. The unidirectional nature of these phenomena is the result of a thermodynamic state function called entropy (S). Entropy is the measure of the extent to which the energy is dispersed throughout a system, or in other words, it is proportional to the degree of disorder of a...
35.4K
01:18Entropy
3.6K
The first law of thermodynamics is quantitatively formulated via an equation relating the internal energy of a system, the heat exchanged by it, and the work done on it. A quantitative formulation of the second law of thermodynamics leads to defining a state function, the entropy.
When an ideal gas expands isothermally, the disorder in the gas increases. From the molecular perspective, the gas molecules have more volume to move around in.
Consider an infinitesimal step in the expansion, which...
When an ideal gas expands isothermally, the disorder in the gas increases. From the molecular perspective, the gas molecules have more volume to move around in.
Consider an infinitesimal step in the expansion, which...
3.6K
01:28True Stress and True Strain
830
Engineering stress is calculated as the load divided by the original, undeformed cross-sectional area. It approximates a material under load. This approximation is especially relevant post-yield in ductile materials. Though engineering stress-strain diagrams are often used for their convenience and accessibility, they can sometimes fall short in accuracy, particularly when dealing with large strain values.
In contrast, true stress offers a more precise portrayal. It is computed by dividing the...
In contrast, true stress offers a more precise portrayal. It is computed by dividing the...
830
03:00Standard Entropy Change for a Reaction
24.2K
Entropy is a state function, so the standard entropy change for a chemical reaction (ΔS°rxn) can be calculated from the difference in standard entropy between the products and the reactants.
24.2K
01:22Chronic Obstructive Pulmonary Disease
2.5K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.5K
01:25Chronic Kidney Disease I: Introduction
697
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
697