Video Experimental Relacionado
Updated: Jan 28, 2026
09:56
Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment
Published on: April 30, 2019
9.6K
Un caso de pancreatitis inducida por fármacos
Muskan Shrestha1, Pratick Shrestha2, Adarsha Mahaseth3
1Manmohan Cardiothoracic Vascular and Transplant Center Kathmandu Nepal.
Clinical case reports
|January 26, 2026
Resumen
La ciprofloxacina, un antibiótico, puede causar raramente pancreatitis inducida por fármacos (DIP), una afección grave. La interrupción rápida del medicamento y la atención de apoyo condujeron a una rápida recuperación en un paciente con este infrecuente efecto adverso.
Área de la Ciencia:
- Gastroenterología; Farmacología; Medicina Interna
Sus antecedentes:
- La pancreatitis inducida por fármacos (DIP) es una causa rara pero significativa de dolor abdominal agudo.; Los casos de DIP asociados con ciprofloxacina, un antibiótico fluoroquinolónico, son excepcionalmente infrecuentes.
Objetivo del estudio:
- Informar un caso raro de pancreatitis inducida por fármacos (DIP) causada por ciprofloxacina.; Destacar la importancia de considerar la DIP en pacientes con dolor abdominal durante la terapia con fluoroquinolonas.
Principales métodos:
- Reporte de caso de una mujer de 35 años que presenta dolor epigástrico agudo.; El estudio diagnóstico incluyó pruebas de laboratorio (amilasa, lipasa) y TC con contraste.; Exclusión de etiologías comunes de pancreatitis (cálculos biliares, alcohol, etc.).; Evaluación de causalidad utilizando la Escala de Naranjo y la Clasificación de Badalov.
Principales resultados:
- La paciente desarrolló pancreatitis grave 3 días después de automedicarse con ciprofloxacina para la diarrea.; Niveles elevados de amilasa y lipasa séricas, con TC que confirma pancreatitis intersticial aguda.; Se excluyeron causas comunes y se identificó la ciprofloxacina como el probable agente causal.; La interrupción de la ciprofloxacina y la atención de apoyo resultaron en una rápida mejoría clínica y bioquímica en 4 días.
Conclusiones:
- La ciprofloxacina puede ser una causa rara de pancreatitis inducida por fármacos.; El reconocimiento temprano y la retirada del fármaco causante son cruciales para obtener resultados favorables.; Este caso enfatiza la necesidad de considerar la DIP en pacientes con dolor abdominal agudo durante el tratamiento con fluoroquinolonas.
Videos de Conceptos Relacionados
01:26Pancreatic Juice and Secretion
2.9K
Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
2.9K
01:27Acute Pancreatitis I: Introduction
1.2K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.2K
01:24Chronic Pancreatitis I: Introduction
725
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
725
01:29Chronic Pancreatitis II: Collaborative Care
349
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
349
01:25Pharmacokinetics: Drug–Drug Interactions
428
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
428
01:09Bioequivalence of Drugs: Drugs with Multiple Indications
156
The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
156