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RM inicial normal, lesión del esplenio tardía en la enfermedad de Marchiafava-Bignami
Tsuyoshi Nojima1, Ryo Tanabe1,2, Takafumi Obara1
1Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine Dentistry and Pharmaceutical Sciences, Okayama University Okayama Okayama Prefecture Japan.
Clinical case reports
|January 26, 2026
Resumen
La enfermedad de Marchiafava-Bignami (EMB) puede no aparecer en las resonancias magnéticas iniciales. Las imágenes repetidas son cruciales para los pacientes con trastorno por consumo de alcohol, ya que las lesiones del esplenio que indican EMB pueden desarrollarse más tarde, lo que evita un diagnóstico tardío.
Área de la Ciencia:
- Neurología
- Radiología
- Neurociencia Nutricional
Sus antecedentes:
- La enfermedad de Marchiafava-Bignami (EMB) es un trastorno neurológico raro.
- Se asocia principalmente con el consumo crónico de alcohol y la posterior deficiencia de tiamina.
- El diagnóstico temprano puede ser un desafío debido a síntomas y hallazgos de imagen iniciales inespecíficos.
Objetivo del estudio:
- Destacar el potencial de hallazgos normales en la RM temprana en la enfermedad de Marchiafava-Bignami.
- Enfatizar la importancia de la neuroimagen repetida en poblaciones de riesgo.
- Subrayar la utilidad diagnóstica del reconocimiento de la evolución de las lesiones del esplenio.
Principales métodos:
- Revisión de casos clínicos y hallazgos de neuroimagen en pacientes con sospecha de EMB.
- Correlación de los resultados de la RM con la presentación clínica y el estado nutricional.
- Análisis de los cambios temporales en las lesiones del esplenio en imágenes seriadas.
Principales resultados:
- Las resonancias magnéticas iniciales en pacientes con EMB pueden presentar hallazgos normales o sutiles.
- Las lesiones del esplenio, características de la EMB, pueden manifestarse o progresar en imágenes repetidas.
- El diagnóstico tardío a menudo se relaciona con la ausencia inicial de anomalías definitivas en la RM.
Conclusiones:
- Los hallazgos tempranos de la RM en la enfermedad de Marchiafava-Bignami pueden ser engañosamente normales.
- La RM seriada es esencial para diagnosticar la EMB en personas con trastorno por consumo de alcohol o riesgo de deficiencia de tiamina.
- El reconocimiento temprano de la evolución de las lesiones del esplenio en las imágenes de seguimiento es fundamental para una intervención oportuna y mejores resultados.
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