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Reporte de caso: Un caso extremadamente raro de STUMP epitelioide
Danjie Li1, Yibei Guan1, Ziqiu He1
1Department of Obstetrics and Gynecology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in oncology
|January 26, 2026
Resumen
Los tumores de músculo liso epitelioides de potencial maligno desconocido (STUMP) son tumores uterinos raros. Este caso destaca el potencial de malignidad del STUMP epitelioide y la importancia de una evaluación preoperatoria exhaustiva para un diagnóstico y tratamiento precisos.
Área de la Ciencia:
- Oncología Ginecológica; Patología; Oncología Quirúrgica
Sus antecedentes:
- Los leiomiomas uterinos son tumores benignos comunes.; El STUMP epitelioide es un subtipo raro con potencial de malignidad.; La morfología epitelioide en tumores de músculo liso sugiere una mayor agresividad.
Objetivo del estudio:
- Presentar un caso de STUMP epitelioide.; Enfatizar los desafíos diagnósticos y el potencial de malignidad del STUMP epitelioide.; Destacar la importancia de la evaluación preoperatoria exhaustiva.
Principales métodos:
- Presentación de caso de una mujer de 45 años con sangrado uterino anormal.; El diagnóstico inicial sugirió un tumor mesenquimatoso uterino de bajo grado de malignidad.; El manejo quirúrgico incluyó histerectomía, resección de anexos y biopsia de ganglios linfáticos.
Principales resultados:
- La patología postoperatoria confirmó STUMP epitelioide con crecimiento infiltrativo, lo que indica potencial maligno.; La paciente no tuvo recurrencia a los 8 meses de seguimiento después de la cirugía sin terapia adyuvante.; Las células tumorales eran pequeñas, redondas a fusiformes con leve pleomorfismo y 2-3 figuras mitóticas por campo de gran aumento (HPF).
Conclusiones:
- El STUMP epitelioide requiere una evaluación preoperatoria exhaustiva, que incluya imágenes avanzadas (RM, TC), para evitar diagnósticos erróneos.; El diagnóstico preciso es crucial para establecer estrategias terapéuticas y pronósticas apropiadas.; El diagnóstico y manejo rápidos son esenciales para pacientes con tumores uterinos potencialmente agresivos.
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