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Reporte de caso: Neumonitis intersticial aguda inducida por furmonertinib

Yong-Liang Niu¹, Ying Yang², Jing-Feng Shi¹

¹Department of Respiratory and Critical Care Medicine, No. 2 People's Hospital of Fuyang City, Fuyang, China.

Frontiers in pharmacology

|January 26, 2026

Resumen

El furmonertinib, un TKI de EGFR, puede causar neumonitis intersticial (NI) a pesar de su perfil de seguridad general. El diagnóstico y la intervención tempranos son cruciales para manejar este evento adverso en pacientes con adenocarcinoma de pulmón.

Área de la Ciencia:

Oncología
Farmacología
Neumología

Sus antecedentes:

El furmonertinib es un inhibidor de la tirosina quinasa del receptor del factor de crecimiento epidérmico (EGFR-TKI) irreversible de tercera generación para el adenocarcinoma de pulmón (LUAD) con mutación EGFR.
Aunque generalmente bien tolerado, la neumonitis intersticial (NI) grave relacionada con el fármaco no se había reportado previamente.

Objetivo del estudio:

Informar un caso raro de neumonitis intersticial (NI) inducida por furmonertinib.
Enfatizar la importancia del reconocimiento temprano y el manejo de este evento adverso.

Principales métodos:

Reporte de caso de una mujer de 71 años con LUAD con mutación EGFR tratada con furmonertinib.
Evaluación clínica, exclusión de otras causas de neumonía intersticial y diagnóstico de NI relacionada con furmonertinib.

Principales resultados:

El paciente desarrolló disnea aguda severa, consolidación pulmonar bilateral difusa e hipoxemia en el día 97 del tratamiento con furmonertinib.
Se estableció el diagnóstico de NI inducida por furmonertinib después de excluir otras causas.
El paciente logró un resultado favorable con diagnóstico e intervención oportunos.

Conclusiones:

El furmonertinib puede inducir neumonitis intersticial (NI) en pacientes con adenocarcinoma de pulmón con mutación EGFR.
El reconocimiento temprano y el manejo rápido son esenciales para revertir este evento adverso grave.
El manejo eficaz puede preservar las opciones de tratamiento posteriores para pacientes con LUAD.

Palabras clave:

TKI de EGFR reacción adversa a medicamentos furmonertinib neumonitis intersticial cáncer de pulmón

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