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La compresión superficial altera las mediciones in vivo de rigidez, viscosidad y anisotropía de VisR en el seno
Anna V Phillips1, Cherie M Kuzmiak2, Doreen Steed2
1Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Chapel Hill, NC 27514 USA.
IEEE open journal of ultrasonics, ferroelectrics, and frequency control
|January 26, 2026
Resumen
La compresión superficial afecta significativamente las mediciones de ultrasonido de respuesta viscoelástica (VisR) de la rigidez y viscosidad del tejido mamario, especialmente en mamas densas. La estandarización de la compresión es crucial para el diagnóstico preciso del cáncer de mama mediante imágenes de VisR.
Área de la Ciencia:
- Ultrasonido biomédico
- Imagenología médica
- Biofísica
Sus antecedentes:
- El ultrasonido de respuesta viscoelástica (VisR) es una técnica de imagen no invasiva y de bajo costo para evaluar la rigidez y viscosidad del tejido.
- VisR muestra potencial para el diagnóstico del cáncer de mama, mejorando potencialmente la detección en mamas densas donde la mamografía es menos efectiva.
- Estudios preliminares indican que VisR puede diferenciar lesiones mamarias malignas y benignas según la rigidez, viscosidad y anisotropía.
Objetivo del estudio:
- Evaluar el impacto de la compresión superficial aplicada en las mediciones de VisR en el tejido mamario.
- Evaluar las diferencias en los efectos de la compresión entre mujeres con mamas densas y no densas.
- Determinar la influencia de la compresión en el desplazamiento pico (PD), la elasticidad relativa (RE), la viscosidad relativa (RV) y el grado de anisotropía (DoA).
Principales métodos:
- Un estudio clínico aprobado por la IRB que involucra a 20 mujeres sin patologías mamarias conocidas.
- Se realizaron mediciones de VisR de PD, RE, RV y DoA bajo diferentes niveles de compresión superficial.
- La densidad mamaria de las participantes se clasificó, y 10/20 tenían mamas densas según mamografía.
Principales resultados:
- La compresión superficial afectó significativamente las mediciones de PD, RE y RV in vivo.
- La rigidez (PD y RE) aumentó significativamente con la compresión, especialmente en mujeres con mamas densas.
- El efecto de la compresión en el DoA varió (aumentó, disminuyó o no cambió), sin diferencias significativas entre los grupos de densidad mamaria.
Conclusiones:
- La compresión superficial aplicada es un factor significativo que influye en las mediciones de VisR del tejido mamario.
- Se recomienda la estandarización y el monitoreo de la compresión para la obtención de imágenes clínicas de VisR de mama, particularmente en mujeres con mamas densas.
- Se necesita más investigación para establecer rangos de deformación óptimos para mediciones de VisR repetibles.
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