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Efectos de la rTMS combinada con rPMS en la lesión completa del nervio mediano posoperatoria: protocolo de estudio
Xianggui Chen1, Jiali Lin1,2,3, Zihang Chen2
1Department of Rehabilitation Medicine, Shanghai Jing'an District Central Hospital, Shanghai, China.
Trials
|January 26, 2026
Resumen
Este estudio investiga los efectos combinados de la estimulación magnética periférica repetitiva (rPMS) y la estimulación magnética transcraneal repetitiva (rTMS) para la rehabilitación de la lesión del nervio mediano posoperatoria (PMNI). Los hallazgos tienen como objetivo desarrollar técnicas innovadoras de estimulación magnética para mejorar los resultados de los pacientes.
Área de la Ciencia:
- Neurología
- Medicina de Rehabilitación
- Ingeniería Biomédica
Sus antecedentes:
- Las lesiones de nervios periféricos (PNI) a menudo causan déficits funcionales significativos.
- La estimulación magnética periférica repetitiva (rPMS) y la estimulación magnética transcraneal repetitiva (rTMS) son técnicas de neuromodulación establecidas.
- La eficacia combinada de la rPMS y la rTMS para la PNI, particularmente la lesión del nervio mediano posoperatoria (PMNI), sigue sin explorarse en profundidad.
Objetivo del estudio:
- Evaluar el efecto terapéutico de la rPMS y la rTMS combinadas en la PMNI.
- Explorar los mecanismos neurofisiológicos subyacentes de esta intervención combinada utilizando espectroscopía funcional de infrarrojo cercano (fNIRS).
Principales métodos:
- Un ensayo controlado aleatorizado prospectivo, monocéntrico, que involucra a 60 participantes con PMNI.
- Participantes asignados a cuatro grupos: intervención convencional, rPMS + rTMS simulada, rPMS simulada + rTMS y rPMS + rTMS.
- Intervenciones administradas durante 12 semanas con evaluaciones al inicio, a las 6 y 12 semanas, midiendo la fuerza de agarre, pruebas sensoriales (SW, 2PD), destreza (PPT) y velocidades de conducción nerviosa (MCV, SCV).
Principales resultados:
- El análisis de datos está pendiente de la finalización del período de intervención de 12 semanas y las evaluaciones posteriores.
- Los resultados funcionales, incluida la fuerza de agarre, la percepción sensorial y la destreza, se compararán entre los grupos.
- Los cambios en las velocidades de conducción motora y sensorial indicarán la recuperación nerviosa.
- Los datos de fNIRS dilucidarán la modulación de la actividad cerebral.
Conclusiones:
- Este protocolo de estudio está diseñado para proporcionar información crucial sobre la eficacia de la estimulación magnética combinada para la PMNI.
- Se espera que los resultados respalden el desarrollo de estrategias de neuromodulación integradas y novedosas para la rehabilitación de lesiones de nervios periféricos.
- Los hallazgos pueden establecer un nuevo estándar de atención para el manejo de la PMNI.
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