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Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Gross Anatomy of the Lungs01:17

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Video Experimental Relacionado

Updated: Jan 28, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Enfermedad pulmonar intersticial tóxica en bovinos

Claudio S L Barros1, Franklin Riet-Correa2, Ricardo E Mendes3

  • 1Laboratory of Anatomic Pathology, School of Veterinary Medicine and Animal Sciences, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|January 27, 2026
PubMed
Resumen

Los agentes tóxicos causan enfermedad pulmonar intersticial en bovinos, provocando neumonía intersticial. El diagnóstico requiere investigar la exposición a toxinas como L-triptófano, 4-ipomeanol, plantas tóxicas y dióxido de nitrógeno.

Palabras clave:
bovinosenfermedad pulmonar intersticialneumonía intersticialneumotoxina

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Área de la Ciencia:

  • Patología Veterinaria; Toxicología; Neumología

Sus antecedentes:

  • La enfermedad pulmonar intersticial (ILD) en bovinos implica lesiones en la pared alveolar y el intersticio bronquiolar.
  • Los agentes tóxicos son una causa importante de ILD en bovinos, que a menudo se presenta como neumonía intersticial.

Objetivo del estudio:

  • Revisar las sustancias clave que causan ILD en bovinos.
  • Discutir la epidemiología, los signos clínicos, la patogénesis y las lesiones asociadas con estas toxinas.

Principales métodos:

  • Revisión de literatura sobre agentes tóxicos que causan ILD en bovinos.
  • Análisis de datos epidemiológicos, presentaciones clínicas y hallazgos patológicos.
  • Discusión de los desafíos y limitaciones diagnósticas.

Principales resultados:

  • Se identificaron las principales toxinas: L-triptófano, 4-ipomeanol, plantas tóxicas (Perilla frutescens, Zieria arborescens) y dióxido de nitrógeno (NO2).
  • Se destacaron signos clínicos y lesiones superpuestos, lo que complica el diagnóstico.
  • Se enfatizó la dificultad en la confirmación de laboratorio debido al rápido metabolismo de las toxinas.

Conclusiones:

  • El diagnóstico definitivo de ILD tóxica en bovinos depende en gran medida de una investigación epidemiológica exhaustiva y de la exposición confirmada.
  • Comprender las toxinas específicas y sus fuentes es crucial para la prevención y el manejo.
  • Puede ser necesaria más investigación para mejorar los métodos de diagnóstico de toxinas inestables.