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Una hidrogel a base de 5-fluorouracilo incrustada con quercetina remodela el microambiente tumoral para una

Yiping Li^1,2,3,4, Peipei Zhao^2,3,5, Junru Li^2,3,5

¹Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.

Advanced healthcare materials

|January 27, 2026

Resumen

Una nueva hidrogel administra 5-fluorouracilo y quercetina para combatir el cáncer de mama triple negativo (CMTN). Este enfoque de quimioinmunoterapia reduce los macrófagos asociados a tumores y mejora la inmunidad antitumoral, mostrando una gran promesa para el tratamiento del CMTN.

Área de la Ciencia:

Ingeniería Biomédica; Investigación Oncológica; Inmunoterapia

Sus antecedentes:

El tratamiento del cáncer de mama triple negativo (CMTN) se enfrenta a desafíos debido a la toxicidad de la quimioterapia y a los microambientes tumorales (TME) inmunosupresores.; Las estrategias de quimioinmunoterapia existentes para el CMTN están limitadas por estos factores.

Objetivo del estudio:

Desarrollar una nueva hidrogel inyectable (Q-5FDHG) para la liberación sostenida de 5-fluorouracilo (5FU) y quercetina (Que).; Evaluar la eficacia terapéutica de doble acción de Q-5FDHG en modelos de CMTN mediante la modulación del TME y la mejora de la inmunidad antitumoral.

Principales métodos:

Se diseñó una hidrogel de ADN inyectable a base de 5-fluorouracilo incrustada con quercetina (Q-5FDHG) mediante amplificación de ADN.; Se administró Q-5FDHG en modelos murinos ortotópicos de CMTN.; Se evaluó el crecimiento tumoral, la metástasis pulmonar y las respuestas inmunitarias.

Principales resultados:

La Q-5FDHG demostró una liberación progresiva de 5FU y Que.; La quercetina atenuó la secreción del ligando de quimiocinas motivo C C 2 (CCL2), reduciendo el reclutamiento de macrófagos asociados a tumores y remodelando el TME.; El 5FU inhibió la proliferación tumoral, indujo la muerte celular inmunogénica (ICD) y mejoró la inmunogenicidad tumoral, lo que condujo a una eficacia antitumoral significativa y a una reducción de la metástasis.

Conclusiones:

La Q-5FDHG ofrece una estrategia dual para superar las limitaciones del tratamiento del CMTN.; Este enfoque de quimioinmunoterapia, que utiliza 5FU y quercetina, muestra un potencial significativo para el tratamiento del CMTN con una toxicidad sistémica reducida y mejores resultados terapéuticos.; El estudio proporciona una estrategia prometedora para la traslación clínica en la terapia del CMTN.

Palabras clave:

5-fluorouracilo hidrogel de ADN quimioinmunoterapia quercetina cáncer de mama triple negativo

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