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La micosis fungoide es una proliferación de múltiples subclones mutacionales

Ryoma Honda^1,2, Toshihisa Hamada¹, Makoto Sugaya¹

¹Department of Dermatology, International University of Health and Welfare, Narita, Japan.

The Journal of dermatology

|January 27, 2026

Abstract:

Mycosis fungoides (MF) is a unique type of lymphoma with an excellent prognosis presenting with a wide variety of clinical and histological findings. Recent sophisticated research techniques have revealed that very slow changes in the clinical and histological pictures of one patient over time are due to intratumoral heterogeneity. This means the distribution of different subclones into individual skin lesions and the accumulation of genomic and epigenomic changes in known pathways, starting from immature T-cell precursors. MF is now recognized as the proliferation of multiple mutational subclones that originate from immature T-cell precursors with malignant potential. This may explain why there are so many case reports of MF accompanied by T-cell lymphoproliferative disorders or cutaneous T-cell lymphomas. In addition, the distinction between "transformation" and "complication" of MF may depend on where the disease branches in the T-cell lineage development and the extent of the disease entity defined by MF.

Palabras clave:

trastornos linfoproliferativos CD30+heterogeneidad intratumoral micosis fungoide células T de memoria residente

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