Video Experimental Relacionado

Updated: Jan 28, 2026

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Published on: October 24, 2018

Liberación de micropartículas y nanopartículas poliméricas de circuitos de derivación cardiopulmonar y oxigenación

Lars Saemann¹, Markus Stiller¹, Hardik Vaghasiya²

¹Department of Cardiac Surgery, 14942 University Hospital Halle , Halle (Saale), Germany.

Biomedizinische Technik. Biomedical engineering

|January 27, 2026

Resumen

Los circuitos de derivación cardiopulmonar y oxigenación por membrana extracorpórea liberan micropartículas y nanopartículas poliméricas (MNP). Los niveles de MNP aumentan con el tiempo de uso, lo que podría contribuir a efectos adversos para la salud durante la circulación extracorpórea.

Área de la Ciencia:

Ciencia de Biomateriales
Ingeniería de Dispositivos Médicos
Toxicología

Sus antecedentes:

Los circuitos de derivación cardiopulmonar (CPB) y oxigenación por membrana extracorpórea (ECMO) o soporte vital (ECLS) son dispositivos médicos esenciales.
Estos circuitos están construidos con polímeros, lo que genera preocupación sobre la liberación de micropartículas y nanopartículas (MNP).
Las MNP están implicadas en la inflamación, el estrés oxidativo y la apoptosis, lo que refleja efectos secundarios conocidos de la circulación extracorpórea.

Objetivo del estudio:

Investigar la liberación de micropartículas y nanopartículas poliméricas (MNP) de los circuitos de CPB y ECMO/ECLS.
Cuantificar la liberación de MNP y caracterizar los tipos de polímeros involucrados.

Principales métodos:

Se operaron circuitos de CPB y ECMO/ECLS con solución salina durante 5 horas y 7 días, respectivamente.
Se recolectaron y filtraron muestras, y las MNP se detectaron y cuantificaron mediante microscopía óptica y espectroscopía micro Raman.

Principales resultados:

Se detectaron cloruro de polivinilo (PVC) y metacrilato de polimetilo (PMMA) en circuitos de CPB.
Se encontró tereftalato de polietileno (PET) después de 5 horas en CPB.
Los circuitos de ECMO/ECLS mostraron acumulación dependiente del tiempo de fragmentos poliméricos, incluyendo polietileno (PE), poliestireno (PS), PET y PVC.
El tamaño de las partículas aumentó de <2 µm a >10 µm con el tiempo de circulación prolongado.

Conclusiones:

Los circuitos de CPB y ECMO/ECLS liberan demostrablemente MNP en la circulación.
La cantidad de MNP liberadas aumenta con la duración del uso del circuito.
Se justifica una mayor investigación para explorar las implicaciones para la salud de estas MNP identificadas.

Palabras clave:

envejecimiento derivación cardiopulmonar oxigenación por membrana extracorpórea micropartícula microplástico nanoplástico

Más Videos Relacionados

Cardiopulmonary Bypass in a Mouse Model: A Novel Approach

Cardiopulmonary Bypass in a Mouse Model: A Novel Approach

Published on: September 22, 2017

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

Published on: March 23, 2018

Videos de Conceptos Relacionados

Energy-releasing Steps of Glycolysis

Energy-releasing Steps of Glycolysis

Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...

Cardiopulmonary Resuscitation I: Adult

Cardiopulmonary Resuscitation I: Adult

Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...

Second-Order Circuits

Second-Order Circuits

Integrating two fundamental energy storage elements in electrical circuits results in second-order circuits, encompassing RLC circuits and circuits with dual capacitors or inductors (RC and RL circuits). Second-order circuits are identified by second-order differential equations that link input and output signals.
Input signals typically originate from voltage or current sources, with the output often representing voltage across the capacitor and/or current through the inductor. For example, in...

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...

Actin Polymerization

Actin Polymerization

Actin polymerization occurs through the head-to-tail association of binding sites on monomeric actin or G-actin to form filamentous or F-actin. The polymerization can be divided into three phases ̶ nucleation, elongation, and steady-state phase.
The nucleation phase involves forming a stable nucleus consisting of three actin monomers to form a new actin filament. Actin-binding proteins such as formins and Arp2/3 complex help filament growth post-nucleation. The Formins form straight...