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Neuropatía Óptica Isquémica No Arterítica Asociada con el Uso de Semaglutida
Irish medical journal
|January 27, 2026
Resumen
Se reportó un caso de pérdida súbita de visión en un paciente diabético que tomaba Semaglutida (un agonista del receptor GLP-1). Esto resalta un riesgo potencial de neuropatía óptica isquémica anterior no arterítica (NAION) asociado con estos medicamentos.
Área de la Ciencia:
- Oftalmología
- Endocrinología
- Farmacología
Sus antecedentes:
- La neuropatía óptica isquémica anterior no arterítica (NAION) es una causa principal de pérdida de visión repentina e indolora.
- Los agonistas del receptor del péptido similar al glucagón tipo 1 (GLP-1RA) se prescriben cada vez más para el control de la diabetes tipo 2.
- La obesidad y la diabetes son factores de riesgo conocidos de eventos vasculares, incluida la NAION.
Objetivo del estudio:
- Informar un caso de NAION en un paciente que usa Semaglutida.
- Crear conciencia sobre la posible asociación entre los agonistas del receptor GLP-1 (GLP-1RA) y la NAION.
- Contribuir a la comprensión de los factores de riesgo de NAION en pacientes diabéticos.
Principales métodos:
- Informe de caso de un hombre obeso de 50 años con NIDDM.
- Presentación clínica de pérdida de visión repentina e indolora en el ojo derecho.
- Estudio diagnóstico que incluye evaluación de la agudeza visual y tomografía de coherencia óptica (OCT) que confirma el edema del nervio óptico.
Principales resultados:
- El paciente fue diagnosticado con neuropatía óptica isquémica anterior no arterítica (NAION).
- Se suspendió el tratamiento con Semaglutida.
- Se confirmó edema del nervio óptico mediante OCT.
Conclusiones:
- Los agonistas del receptor GLP-1 (GLP-1RA), incluida la Semaglutida, están emergiendo como posibles factores de riesgo de NAION.
- Este caso representa un informe novedoso de NAION asociado con Semaglutida en Irlanda.
- Se necesita más investigación para dilucidar la relación entre los GLP-1RA y la NAION.
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