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Pacientes con lupus eritematoso sistémico de reciente aparición usan más antidepresivos que controles pareados: un
Simo Kariniemi1, Pia Elfving1,2, Lauri J Virta3
1Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
Medicine
|January 27, 2026
Resumen
Los pacientes con lupus eritematoso sistémico (LES) muestran un aumento en el uso de antidepresivos, lo que sugiere trastornos del estado de ánimo en el momento del diagnóstico. El uso de antipsicóticos se mantuvo similar entre los pacientes con LES y los controles, lo que indica trastornos psicóticos raros.
Área de la Ciencia:
- Reumatología; Psiquiatría; Farmacología
Sus antecedentes:
- El lupus eritematoso sistémico (LES) es una enfermedad autoinmune con asociaciones conocidas con problemas de salud mental.; Comprender los patrones de uso de medicamentos para la salud mental es crucial para la atención integral del paciente con LES.
Objetivo del estudio:
- Evaluar la cantidad, frecuencia y riesgo de uso de medicamentos antidepresivos y antipsicóticos en pacientes con LES de reciente aparición.; Comparar el uso de medicamentos entre pacientes con LES y un grupo de control pareado.
Principales métodos:
- Estudio de casos y controles utilizando datos de reembolso y compra de medicamentos de registros nacionales.; Inclusión de 1006 casos de LES y 3005 controles, con datos de medicación rastreados desde 1 año antes del diagnóstico hasta 5 años después del diagnóstico.; Se utilizó la Dosis Diaria Definida (DDD) para cuantificar el consumo de medicamentos, y se calcularon los cocientes de riesgos ajustados para las compras de antidepresivos.
Principales resultados:
- Los pacientes con LES exhibieron un consumo diario medio significativamente mayor de antidepresivos tanto antes como después del diagnóstico en comparación con los controles (P < 0,001).; El cociente de riesgos ajustado para la compra de antidepresivos fue de 1,45 (IC del 95%: 1,19-1,77; P < 0,001) para los pacientes con LES.; No se observaron diferencias significativas en el uso de medicación antipsicótica entre los pacientes con LES y los controles.
Conclusiones:
- El aumento del uso de antidepresivos en los casos de LES sugiere una mayor prevalencia de trastornos del estado de ánimo concurrentes con el diagnóstico de LES.; El uso similar de antipsicóticos indica que los trastornos psicóticos crónicos que requieren tratamiento a largo plazo son poco comunes en el LES.; Los hallazgos resaltan la importancia de la detección y el manejo de los trastornos del estado de ánimo en pacientes con LES.
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