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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
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Angle of Twist: Problem Solving01:13

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An electric motor applies a torque of 700 N·m to an aluminum shaft, triggering a stable rotation. Two pulleys, B and C, are subjected to torques of 300 N·m and 400 N·m, respectively. The modulus of rigidity is provided as 25 GPa. With the knowledge of the length and diameter of each segment, the twist angle between the two pulleys can be computed. First, a section cut is made between pulleys B and C, and the cut cross-section is analyzed using a free-body diagram. Given that the torque...
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Video Experimental Relacionado

Updated: Jan 28, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

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Cambios Estructurales y Vasculares Coroideos en el Glaucoma Primario de Ángulo Cerrado Temprano

Hui Liu1,2, Shuang Liang2, Xiaoli Liu2

  • 1Hebei Medical University Clinical Medicine Postdoctoral Research Station (The Second Hospital), People's Republic of China.

Journal of glaucoma
|January 27, 2026
PubMed
Resumen

El glaucoma primario de ángulo cerrado (PACG) temprano se asocia con un mayor grosor coroideo (CT) y un mayor índice de vascularidad coroidea (CVI). Estos cambios, particularmente el CVI, pueden indicar la progresión de la enfermedad en pacientes con PACG.

Palabras clave:
grosor coroideoíndice de vascularidad coroideaglaucoma primario de ángulo cerradoangiografía por tomografía de coherencia óptica de fuente barrida

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Área de la Ciencia:

  • Oftalmología
  • Investigación sobre Glaucoma
  • Imagenología Coroidea

Sus antecedentes:

  • El glaucoma primario de ángulo cerrado (PACG) es una causa importante de pérdida de visión.
  • Comprender los cambios patológicos tempranos en el PACG es crucial para una intervención oportuna.
  • Las características coroideas como el grosor (CT) y el índice de vascularidad (CVI) son cada vez más reconocidas como biomarcadores potenciales en el glaucoma.

Objetivo del estudio:

  • Investigar el grosor coroideo (CT) y el índice de vascularidad coroidea (CVI) en el glaucoma primario de ángulo cerrado (PACG) temprano utilizando angiografía por tomografía de coherencia óptica de fuente barrida (SS-OCTA).

Principales métodos:

  • Se comparó el CT y el CVI en 86 pacientes con PACG temprano y 79 controles sanos utilizando escaneos maculares y del disco óptico de SS-OCTA.
  • Se analizaron regiones maculares de 12x12 mm y del disco óptico de 6x6 mm.
  • Se emplearon análisis de regresión lineal univariante y multivariante para evaluar las asociaciones con la edad y la longitud axial.

Principales resultados:

  • Los ojos con PACG temprano mostraron un CT y un CVI significativamente más gruesos en las regiones maculares en comparación con los controles sanos (P<0.05).
  • El aumento del CT y CVI subfoveales se asoció con una edad más joven, diagnóstico de PACG y menor longitud axial.
  • Estas diferencias en CT y CVI persistieron incluso después de ajustar por edad y longitud axial (P<0.01).

Conclusiones:

  • El PACG temprano se asocia con un mayor grosor coroideo (CT) y un mayor índice de vascularidad coroidea (CVI) en las regiones anulares maculares.
  • Estas alteraciones coroideas son independientes de la edad y la longitud axial, lo que sugiere un papel en la patogénesis del PACG.
  • El CVI puede ser un indicador más sensible para monitorizar la progresión de la enfermedad en el PACG temprano.