Video Experimental Relacionado

Updated: Jan 29, 2026

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons
07:41

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

Published on: August 6, 2020

8.0K

Discrepancia transcripto-proteína de subunidades de receptores glutamatérgicos en neuronas humanas derivadas de iPSC:

Melania Maria Serafini1, Miriam Midali1, Giacomo Grumelli1

  • 1Department of Pharmacological and Biomolecular Sciences, "Rodolfo Paoletti", Università degli Studi di Milano, Milan, Italy.

Toxicology letters
|January 27, 2026
PubMed
Resumen

Las neuronas derivadas de células madre humanas muestran potencial para la neurotoxicología, pero requieren una maduración más prolongada. Los datos transcripcionales de los receptores de N-metil-D-aspartato (NMDA) y alfa-amino-3-hidroxi-5-metil-4-isoxazolpropiónico (AMPA) no siempre coinciden con los niveles de proteína en estos modelos.

Palabras clave:
Receptor AMPANeuronas humanas derivadas de iPSCReceptor NMDANeurotoxicologíaSinaptogénesisDiscrepancia transcripto-proteína

Más Videos Relacionados

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells10:49

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

Published on: April 14, 2013

11.3K
Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing09:02

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

24.3K

Videos de Conceptos Relacionados

G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
131.9K
Self-Discrepancy Theory02:45

Self-Discrepancy Theory

One influential perspective on what motivates people's behavior is detailed in Tory Higgin's self-discrepancy theory (Higgins, 1987). He proposed that people hold disagreeing internal representations of themselves that lead to different emotional states.  
18.9K
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.7K
Transcription Elongation Factors02:35

Transcription Elongation Factors

Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
13.8K
Self-Discrepancy and Its Effects01:29

Self-Discrepancy and Its Effects

Self-discrepancy theory explains how people compare their actual self to their ideal and ought selves and how mismatches between these self-guides can lead to emotional distress. Developed by E. Tory Higgins, the theory distinguishes among three components of self-concept: the actual self, the ideal self, and the ought self. These refer respectively to how individuals perceive themselves, how they aspire to be, and how they believe they are obligated to be. Emotional well-being, self-esteem,...
312
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

Overview
110.8K