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La duración importa: Adaptación de la terapia antibiótica para la neumonía asociada al ventilador

Tim Rahmel¹, Isabella Traut², Lars Bergmann¹

¹Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Knappschaft Kliniken University Hospital Bochum, Ruhr-University Bochum, 44892 Bochum, Germany.

Antibiotics (Basel, Switzerland)

|January 28, 2026

Resumen

Los ciclos cortos de antibióticos (alrededor de 7 días) son efectivos para la mayoría de los pacientes con neumonía asociada al ventilador (VAP), lo que reduce la toxicidad sin aumentar el fracaso. El tratamiento individualizado y la guía de biomarcadores pueden optimizar aún más la administración de antimicrobianos en la UCI.

Sus antecedentes:

La neumonía asociada al ventilador (VAP) es una infección común en la UCI, tratada históricamente con cursos prolongados de antibióticos.; Esta extensa exposición a los antimicrobianos contribuye a la resistencia y la toxicidad.; La evidencia actual respalda duraciones de tratamiento más cortas para la VAP.

Conclusiones:

Se recomienda una duración de antibióticos predeterminada de aproximadamente 7 días para la VAP.; La extensión del tratamiento debe individualizarse según la respuesta clínica, la bacteriemia y los factores del paciente.; La integración de la evaluación clínica con biomarcadores apoya la administración eficaz de antimicrobianos en la VAP.

Palabras clave:

Pseudomonas spp.duración de los antibióticos administración de antimicrobianos unidad de cuidados intensivos bacilos gramnegativos no fermentadores procalcitonina neumonía asociada al ventilador

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