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FGF2 como un posible supresor de tumores en el adenocarcinoma de pulmón
Shih-Sen Lin1, Hsin-Ying Lu2,3, Tsung-Ming Chang4
1Division of Chest Medicine, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan.
Diagnostics (Basel, Switzerland)
|January 28, 2026
Resumen
El factor de crecimiento de fibroblastos 2 (FGF2) se desregula a la baja en el adenocarcinoma de pulmón (LUAD), actuando como un supresor de tumores. Niveles más bajos de FGF2 se correlacionan con un aumento de metástasis y una menor supervivencia, lo que sugiere su potencial como biomarcador pronóstico para LUAD.
Área de la Ciencia:
- Oncología
- Biología Molecular
- Bioinformática
Sus antecedentes:
- El adenocarcinoma de pulmón (LUAD) a menudo se presenta en etapas avanzadas con metástasis, lo que requiere biomarcadores pronósticos.
- El factor de crecimiento de fibroblastos 2 (FGF2) exhibe roles complejos en el cáncer, y su función en LUAD requiere aclaración.
Objetivo del estudio:
- Identificar genes consistentemente desregulados en LUAD utilizando bioinformática.
- Investigar el papel de FGF2 como biomarcador pronóstico y su efecto sobre la motilidad de las células de LUAD.
Principales métodos:
- Análisis de tres conjuntos de datos de Gene Expression Omnibus (GEO) (GSE19804, GSE18842, GSE18842, GSE19188) para genes diferencialmente expresados (DEGs).
- Análisis de enriquecimiento funcional, construcción de redes de interacción proteína-proteína (PPI) e identificación de genes centrales.
- Validación de la expresión de FGF2 en múltiples plataformas y ensayos funcionales in vitro (migración Transwell, cicatrización de heridas).
Principales resultados:
- Se identificaron 949 DEGs comunes enriquecidos en vías de adhesión celular y metástasis.
- FGF2 se desreguló consistentemente a la baja en tejidos de LUAD y se asoció con una mejor supervivencia general y libre de progresión.
- FGF2 exógeno suprimió significativamente la migración de células de LUAD y la cicatrización de heridas in vitro.
Conclusiones:
- FGF2 exhibe un papel supresor de tumores en LUAD, desregulado a la baja en asociación con la progresión metastásica.
- La expresión de FGF2 está inversamente correlacionada con el mal pronóstico en pacientes con LUAD.
- FGF2 muestra potencial como biomarcador no invasivo para monitorear la metástasis de LUAD.
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