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Updated: Jan 29, 2026
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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
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Determinación de la Distancia Óptima del Dominio de Unión a Heparina en VEGF165 Mediante Simulaciones de Muestreo de
Jung Seok Lee1, Yeon Ju Go1, Young Min Rhee1
1Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
International journal of molecular sciences
|January 28, 2026
Resumen
Este estudio utilizó simulaciones de dinámica molecular para comprender la estructura del factor de crecimiento endotelial vascular 165 (VEGF165). Los hallazgos revelan distancias óptimas para diseñar potentes fármacos de aptámeros dirigidos al VEGF165 para el tratamiento de enfermedades.
Sus antecedentes:
- Vascular endothelial growth factor 165 (VEGF165) is crucial in angiogenesis-related diseases and a therapeutic target.; VEGF165 structure, with its receptor-binding (RBD) and heparin-binding (HBD) domains, is not fully understood.; Dimeric aptamers targeting VEGF165 show promise but require optimized linker lengths for enhanced potency.
Conclusiones:
- The study provides crucial distance information for VEGF165 structure, aiding in understanding its interactions.; Findings offer quantitative guidelines for the rational design of potent aptamer dimers targeting VEGF165.; This research contributes to the development of novel aptamer-based diagnostics and therapeutics for angiogenesis-related diseases.
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