Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

Osmoregulation in Insects01:47

Osmoregulation in Insects

17.6K
Malpighian tubules are specialized structures found in the digestive systems of many arthropods, including most insects, that handle excretion and osmoregulation. The tubules are typically arranged in pairs and have a convoluted structure that increases their surface area.
17.6K
What is Conservation Biology?01:57

What is Conservation Biology?

24.3K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.3K
Conservation of Small Populations02:04

Conservation of Small Populations

17.1K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.1K
Conserved Binding Sites01:49

Conserved Binding Sites

5.1K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.1K
Partial Fractions01:28

Partial Fractions

215
A partial fraction is a component of a rational expression represented as the sum of simpler fractions. When a rational function is expressed as a ratio of two polynomials, it can often be decomposed into a sum of fractions whose denominators are simpler polynomials, typically linear or irreducible quadratic factors. This process is called partial fraction decomposition, and it is used to simplify complex expressions for integration, solving equations, or analysis.Partial fraction decomposition...
215
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

14.4K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.4K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Old worms, new tricks: dynamical instability explains late-life rejuvenation in <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2026
Same author

Reframing biological age as risk-equivalent age.

Nature aging·2025
Same author

Experimental models for keratoconus: Insights and challenges.

Experimental eye research·2024
Same author

Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks.

International journal of molecular sciences·2024
Same author

Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention.

Nature aging·2024
Same author

<i>Drosophila</i>-A Model System for Developmental Biology.

Journal of developmental biology·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: Jan 29, 2026

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals
07:40

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals

Published on: March 13, 2011

21.4K

Reprogramación Parcial Conservada de Insectos a Mamíferos

Nicholas S Tolwinski1, Sheng Fong2,3, Sujithra Shankar1

  • 1Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore.

Cells
|January 28, 2026
PubMed
Resumen
Este resumen es generado por máquina.

El envejecimiento celular implica la disminución de la función, células senescentes y agotamiento de las células madre. La reversión de la plasticidad celular con factores de Yamanaka muestra potencial para extender la vida útil y mejorar la salud en la investigación del envejecimiento.

Palabras clave:
OKSMOSKMSenoterapéuticoenvejecimientolongevidadreprogramación

Más Videos Relacionados

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.4K
Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.5K

Videos de Experimentos Relacionados

Last Updated: Jan 29, 2026

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals
07:40

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals

Published on: March 13, 2011

21.4K
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.4K
Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.5K

Área de la Ciencia:

  • Gerontología y biología celular.
  • Biología de células madre y medicina regenerativa.

Sus antecedentes:

  • El envejecimiento se caracteriza por un declive funcional sistémico, acumulación de células senescentes y disfunción de células madre/progenitoras.
  • Las células diferenciadas poseen plasticidad, permitiendo la reversión a estados pluripotentes a través de factores de Yamanaka.

Objetivo del estudio:

  • Revisar los avances recientes en la reprogramación celular para intervenciones contra el envejecimiento.
  • Explorar el potencial de la plasticidad inducida por factores de Yamanaka para mitigar el declive relacionado con la edad.
  • Proponer nuevas direcciones para el descubrimiento de intervenciones contra el envejecimiento.

Principales métodos:

  • Revisión de la literatura científica reciente sobre plasticidad celular y envejecimiento.
  • Análisis de estudios que utilizan factores de Yamanaka en modelos de envejecimiento.
  • Discusión de tecnologías emergentes como senolíticos y relojes de envejecimiento.

Principales resultados:

  • El tratamiento con factores de Yamanaka demuestra potencial para revertir las características del envejecimiento celular.
  • Estudios en organismos modelo (moscas, ratones) muestran una extensión significativa de la vida.
  • Los senolíticos y los relojes de envejecimiento están emergiendo como herramientas clave en la investigación del envejecimiento.

Conclusiones:

  • La reprogramación celular ofrece una vía prometedora para combatir el declive relacionado con la edad.
  • La investigación adicional sobre las aplicaciones de los factores de Yamanaka podría revolucionar la longevidad y la salud.
  • La integración de la reprogramación con senolíticos y relojes de envejecimiento puede acelerar el descubrimiento de intervenciones.