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Sistemas Eutécticos Terapéuticos Basados en Ácido Caprílico: Una Revisión Enfocada Dentro del Marco de los
Faisal Al-Akayleh1, Ahmed S A Ali Agha2, Ali R Olaimat3
1Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
Resumen
Los sistemas eutécticos terapéuticos basados en ácido caprílico (CA) (THEDES) mejoran la solubilidad, permeabilidad y bioactividad de los fármacos. Estas formulaciones verdes ofrecen una plataforma novedosa para la administración de fármacos, aunque la estabilidad y los aspectos regulatorios requieren una mayor investigación.
Área de la Ciencia:
- Ciencias Farmacéuticas
- Ciencia de Materiales
- Sistemas de Administración de Fármacos
Sus antecedentes:
- Los sistemas eutécticos terapéuticos basados en ácido caprílico (CA) (THEDES) son matrices biofuncionales novedosas.
- Estos sistemas muestran potencial para mejorar la solubilización, permeabilidad y bioactividad de los fármacos.
Objetivo del estudio:
- Revisar y sintetizar la evidencia sobre el diseño, los mecanismos y el rendimiento farmacéutico de los THEDES basados en CA.
- Identificar principios unificadores y direcciones futuras de investigación para los THEDES basados en CA.
Principales métodos:
- Se realizaron búsquedas específicas en bases de datos para identificar estudios relevantes sobre THEDES basados en CA.
- La selección de los estudios identificados se centró en su diseño, mecanismos y rendimiento farmacéutico.
Principales resultados:
- Los THEDES basados en CA mejoran la solubilidad de los fármacos a través de enlaces de hidrógeno y la amorización.
- Se observa una mejora en la permeación transdérmica y transmucosa debido a la cadena anfífila del CA.
- El CA exhibe efectos antimicrobianos y anticancerígenos sinérgicos, actuando como co-terapéutico.
- Se identifican lagunas en la estabilidad a largo plazo, la toxicología y la clasificación regulatoria.
Conclusiones:
- Los THEDES basados en CA ofrecen una plataforma diseñable racionalmente para la administración de fármacos de próxima generación.
- Estos sistemas integran la funcionalidad del disolvente con la actividad terapéutica en una única formulación verde.
- Los enfoques de IA/ML pueden ayudar en la selección y optimización racional de los THEDES basados en CA.
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