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Polarización planar de ADIP endógeno durante la neurulación de Xenopus
Satheeja Santhi Velayudhan1, Keiji Itoh1, Chih-Wen Chu1
1Department of Stem Cell Biology and Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, 10029, USA.
Biology open
|January 28, 2026
Resumen
La proteína de unión a afadina y alfa-actina (ADIP) se reorganiza durante la reparación de tejidos y el cierre del tubo neural, lo que indica que detecta señales mecánicas. Las redes del citoesqueleto regulan esta proteína mecanosensible.
Área de la Ciencia:
- Biología del Desarrollo
- Biología Celular
- Biofísica
Sus antecedentes:
- La polaridad celular coordinada y la localización de proteínas sensibles a la fuerza son cruciales para la morfogénesis de tejidos.
- Comprender cómo las células embrionarias detectan y responden a las señales mecánicas es un desafío clave.
- La proteína de unión a afadina y alfa-actina (ADIP) está implicada en la dinámica de los microtúbulos, la ciliogénesis y la migración celular colectiva.
Objetivo del estudio:
- Investigar la distribución y regulación del ADIP endógeno en embriones tempranos de vertebrados.
- Determinar si el ADIP funciona como una proteína mecanosensible in vivo.
- Elucidar el papel de las redes del citoesqueleto en la polarización del ADIP.
Principales métodos:
- Observación de la localización de ADIP endógeno en embriones de Xenopus durante la reparación de heridas epiteliales y el cierre del tubo neural.
- Agotamiento del componente de polaridad celular planar (PCP) Diversin/Ankrd6.
- Disrupción farmacológica de microtúbulos, F-actina y miosina II no muscular.
Principales resultados:
- El ADIP endógeno exhibe una reorganización y polarización dinámicas durante la reparación de heridas epiteliales.
- El ADIP se enriquece y se polariza planarmente en la placa neural anterior, lo que se correlaciona con las fuerzas mecánicas durante el cierre del tubo neural.
- La polarización del ADIP depende del componente central de la PCP, Diversin/Ankrd6, y de elementos del citoesqueleto (microtúbulos, F-actina, miosina II no muscular).
Conclusiones:
- El ADIP endógeno actúa como una proteína mecanosensible, detectando señales mecánicas a través de la maquinaria del citoesqueleto.
- El ADIP desempeña un papel dependiente del contexto en la regulación de los comportamientos celulares colectivos durante la morfogénesis de vertebrados.
- Los microtúbulos y las redes de actomiosina son esenciales para la polarización del ADIP en el neuroectodermo.
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