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Datos y evidencia del mundo real: pioneros en oncología de precisión
Jingxin Jiang1,2,3, Weiwei Pan1,2,3, Liyang Sun4
1Department of Breast Surgery (Surgical Oncology), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Journal of Zhejiang University. Science. B
|January 28, 2026
Resumen
Los estudios del mundo real (RWS) ofrecen valiosas perspectivas oncológicas más allá de los ensayos clínicos. Mejoran la atención oncológica personalizada al analizar diversas fuentes de datos para obtener mejores resultados de tratamiento.
Área de la Ciencia:
- Oncología
- Evidencia del mundo real
- Medicina de precisión
Sus antecedentes:
- Los estudios del mundo real (RWS) son cada vez más importantes en oncología.
- Complementan los ensayos controlados aleatorizados (ECA) al proporcionar datos de la práctica clínica habitual.
Objetivo del estudio:
- Revisar la implementación, metodología e impacto de los RWS en oncología.
- Explorar cómo los RWS contribuyen a la medicina de precisión y la atención oncológica personalizada.
Principales métodos:
- Análisis sistemático de RWS en oncología.
- Aprovechamiento de diversas fuentes de datos como registros médicos electrónicos (RME), reclamaciones de seguros y registros de pacientes.
Principales resultados:
- Los RWS capturan resultados en poblaciones subrepresentadas y amplían las indicaciones de los medicamentos.
- Evalúan la seguridad y eficacia a largo plazo en entornos del mundo real.
- Las tecnologías emergentes como la IA abordan desafíos como la calidad de los datos y la privacidad.
Conclusiones:
- Los RWS están revolucionando la oncología de precisión.
- La integración de RWS con la investigación clínica permite enfoques de tratamiento más personalizados basados en evidencia del mundo real.
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