Video Experimental Relacionado

Updated: Jan 30, 2026

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
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Acumulación de zinc y respuesta integrada al estrés: desencadenantes de la pérdida de identidad de las células beta

Qing Ma1, Wenjun Xu1, Xuan Wang1

  • 1Institute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Cell research
|January 28, 2026
PubMed
Resumen

La acumulación de zinc causa la pérdida de identidad de las células beta pancreáticas en la diabetes tipo 2 al desencadenar la respuesta integrada al estrés (ISR). La inhibición de la ISR o de la acumulación de zinc protege las células beta, ofreciendo una posible estrategia terapéutica.

Palabras clave:
diabetes tipo 2células beta pancreáticaspérdida de identidad celularacumulación de zincrespuesta integrada al estrésATF4ARXterapias dirigidas

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